Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment

World Journal of Gastroenterology : WJG
Valery VilchezRoberto Gedaly

Abstract

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Liver cancer is generally related to hepatitis B or C infection and cirrhosis. Usually, patients with HCC are asymptomatic and are diagnosed at late stages when surgical treatment is no longer suitable. Limited treatment options for patients with advanced HCC are a major concern. Therefore, there is an urge for finding novel therapies to treat HCC. Liver cancer is highly heterogeneous and involved deregulation of several signaling pathways. Wnt/β-catenin pathway is frequently upregulated in HCC and it is implicated in maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. A great effort in developing selective drugs to target components of the β-catenin pathway with anticancer activity is underway but only a few of them have reached phase I clinical trials. We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance. We also evaluated the use of small molecules targeting the Wnt/β-catenin pathway with potential application for treatment of HCC.

References

Dec 10, 1993·Science·B RubinfeldP Polakis
Feb 19, 1999·Oncogene·M KishidaA Kikuchi
Jun 5, 2003·Biochimica Et Biophysica Acta·Rachel H GilesHans Clevers
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Jan 20, 2004·Cancer Research·Naomoto HaradaMakoto M Taketo
Jan 30, 2004·Cancer Cell·Maina LepourceletRamesh A Shivdasani
Mar 1, 2005·Journal of Clinical Pathology·S Salahshor, J R Woodgett
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Han Chu LeeJack R Wands
Jun 27, 2006·Oncogene·P Laurent-Puig, J Zucman-Rossi
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kumar SukhdeoDaniel R Carrasco
Feb 5, 2008·Cancer Cell·Zhen Fan YangSheung Tat Fan
Mar 19, 2008·Molecular Cancer Therapeutics·Shlomo Handeli, Julian A Simon
May 16, 2008·International Journal of Clinical Practice·W SongK Dou
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Oct 17, 2008·Future Oncology·Catherine CavardChristine Perret
Dec 11, 2008·European Journal of Haematology·Katharina Salome MinkeKarl-Anton Kreuzer
Dec 23, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin CieplySatdarshan P S Monga
Apr 11, 2009·World Journal of Gastroenterology : WJG·Xian-Ming Chen
Aug 8, 2009·International Journal of Cancer. Journal International Du Cancer·Wei WeiSamuel So
Sep 18, 2009·Nature·Shih-Min A HuangFeng Cong
Oct 9, 2009·The New England Journal of Medicine·Junfang JiXin Wei Wang
Apr 3, 2010·Neoplasia : an International Journal for Oncology Research·Rajesh Kumar GandhirajanKarl-Anton Kreuzer
May 29, 2010·International Journal of Clinical Oncology·Masatoshi Kudo
Jun 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fumi Takahashi-Yanaga, Michael Kahn
Jun 19, 2010·International Journal of Molecular Sciences·Boon Yin KhooPrabha Balaram
Oct 5, 2010·Nature Chemical Biology·Curtis A ThorneEthan Lee
Nov 9, 2010·Journal of Hepatology·Sarah Beseme NambotinPhilippe Merle
Dec 25, 2010·Seminars in Cancer Biology·Kari Nichole Nejak-Bowen, Satdarshan P S Monga
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag

❮ Previous
Next ❯

Citations

May 20, 2016·Gut·Béatrice Benoit, Christian Poüs
Nov 8, 2016·Scientific Reports·Bang-Li HuHai-Xing Jiang
May 5, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Melek PehlivanHakkı Ogun Sercan
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiachen ZhengYang Xi
Mar 8, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yang JiaoDong Du
Dec 1, 2017·Journal of Clinical Medicine·Uyen Ngoc MuiStephen K Tyring
Jan 20, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chia-Jui YenWenya Huang
Jun 24, 2017·World Journal of Clinical Oncology·Ioannis A Ziogas, Georgios Tsoulfas
Jan 31, 2018·Oxidative Medicine and Cellular Longevity·Romina MancinelliClaudia Giampietri
Oct 13, 2017·Journal of Cellular and Molecular Medicine·Shu LiuYangfu Jiang
Jul 26, 2019·Journal of Experimental & Clinical Cancer Research : CR·Kai TengDan Xie
Sep 5, 2019·Journal of Gastroenterology and Hepatology·Sung Whan ChaSoon Koo Baik
Jan 5, 2020·Nature Reviews. Gastroenterology & Hepatology·Bin ChenXin Chen
Dec 29, 2016·Oncotarget·Verónica CánovasRosanna Paciucci
May 19, 2020·Bioscience Reports·Jing FengJunping Wang
Feb 12, 2020·Biomedical Reports·Nattpawit KaewnoonualWisuit Pradidarcheep
Nov 9, 2018·Oncology Letters·Ahmad M Al-DaliIngo G H Schmidt-Wolf
Mar 25, 2017·Scientific Reports·Chung-Ming LinHui-Jye Chen
Apr 23, 2017·The Journal of Biological Chemistry·James M DolezalEdward V Prochownik
Aug 15, 2018·Journal of Clinical Medicine·Meng-Yu WuChia-Jung Li
Jan 10, 2019·Therapeutic Advances in Medical Oncology·Nuozhou WangGeorge G Chen
Jul 8, 2019·Molecular Biology Reports·Munmun Panda, Bijesh K Biswal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.