Jan 22, 2013

Targetome profiling, pathway analysis and genetic association study implicate miR-202 in lymphomagenesis

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Aaron E HoffmanYong Zhu

Abstract

miRNAs have been implicated in numerous tumorigenic pathways, and previous studies have associated miR-202 dysregulation with various cancer types, including follicular lymphoma. The miR-202 targetome was identified by ribonucleoprotein immunoprecipitation-microarray (RIP-Chip), and functional interactions among identified targets were investigated using the Ingenuity Pathway Analysis tool. We also conducted a population-based genetic association study of a polymorphism within the miR-202 stem-loop sequence and risk of non-Hodgkin lymphoma. In vitro gain-of-function experiments were further conducted to elucidate the functional significance of the variant. A total of 141 potential members of the miR-202 targetome were identified by a transcriptome-wide RIP-Chip assay. Functional interactions among identified targets suggested that miR-202-regulated genes are involved in biologic pathways relevant for hematologic function and cancer. Consistent with this, a genetic association analysis using human blood samples revealed a significant association between a germline mutation (rs12355840) in the miR-202 precursor sequence and follicular lymphoma risk. An in vitro functional assay further showed that the variant allele resulted in d...Continue Reading

  • References42
  • Citations20

References

Mentioned in this Paper

Biochemical Pathway
Tumor Suppressor Genes
Lymphoma, Non-Hodgkin
Stem-Loop Sequence
Germ-Line Mutation
Ribonucleoprotein Activity
Hairpin Loop Sequence
RNA, Small Temporal
Genetic Association Studies
Candidate Gene Identification

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Angiolo GadducciIlaria Guiggi
© 2020 Meta ULC. All rights reserved