Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children

Infection and Immunity
Linda M MurungiFaith Osier

Abstract

Severe malaria (SM) is a life-threatening complication of infection with Plasmodium falciparum Epidemiological observations have long indicated that immunity against SM is acquired relatively rapidly, but prospective studies to investigate its immunological basis are logistically challenging and have rarely been undertaken. We investigated the merozoite targets and antibody-mediated mechanisms associated with protection against SM in Kenyan children aged 0 to 2 years. We designed a unique prospective matched case-control study of well-characterized SM clinical phenotypes nested within a longitudinal birth cohort of children (n= 5,949) monitored over the first 2 years of life. We quantified immunological parameters in sera collected before the SM event in cases and their individually matched controls to evaluate the prospective odds of developing SM in the first 2 years of life. Anti-AMA1 antibodies were associated with a significant reduction in the odds of developing SM (odds ratio [OR] = 0.37; 95% confidence interval [CI] = 0.15 to 0.90; P= 0.029) after adjustment for responses to all other merozoite antigens tested, while those against MSP-2, MSP-3, Plasmodium falciparum Rh2 [PfRh2], MSP-119, and the infected red blood cell ...Continue Reading

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Citations

Oct 31, 2016·Trends in Parasitology·Andrew TeoStephen J Rogerson
Oct 30, 2016·Frontiers in Microbiology·Susanne H HodgsonSimon J Draper
Jun 25, 2017·Immunology·James TujuFaith H A Osier
Jul 18, 2019·Blood Advances·Natasha M ArcherManoj T Duraisingh
Feb 1, 2020·Immunology and Cell Biology·Elizabeth H AitkenStephen J Rogerson
Jan 9, 2019·Frontiers in Immunology·Elizabeth H AitkenStephen J Rogerson
Nov 17, 2020·Frontiers in Immunology·S Jake GonzalesEvelien M Bunnik
Jul 3, 2017·International Journal for Parasitology·Danika L HillDanny W Wilson
Dec 7, 2021·Frontiers in Cellular and Infection Microbiology·Michelle K MuthuiMelissa C Kapulu

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Methods Mentioned

BETA
PCR
ELISA
enzyme-linked immunosorbent assay
SMA

Software Mentioned

FlowJo
STATA

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