PMID: 8971472Nov 1, 1996Paper

Targets for cancer therapy in the cell cycle pathway

Current Opinion in Oncology
R N Rao

Abstract

Progression through the cell cycle is a complex process that is regulated at many levels by several proteins. We are just beginning to understand how these proteins accomplish this regulation. The p16-cyclin D1.cdk4-pRb pathway is one of the most important pathways, which is altered in a majority of cancers of different types. This review focuses on some of the proteins in this pathway that offer new opportunities for drug discovery. Some guidelines to evaluate the relevance of these proteins as targets for cancer therapy and the importance of developing a combination therapy targeting multiple pathways are also discussed.

Citations

Mar 10, 2000·Biochimica Et Biophysica Acta·J MaiB F Sloane
Dec 26, 2001·Nucleic Acids Research·X ChenY Z Chen
Mar 23, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana KnillováAlice Hlobilková
Jun 17, 2011·Cancer Treatment Reviews·Flora ZagouriDimitrios Pectasides
May 25, 2004·Seminars in Nephrology·James V Donadio, Joseph P Grande
Aug 31, 1999·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M YasunagaN Kitamura
Jul 1, 2004·Bioorganic & Medicinal Chemistry Letters·Rima S Al-awarFaming Zhang
Feb 22, 2002·Experimental Biology and Medicine·Joseph P GrandeKarl A Nath
Dec 18, 2002·Experimental Biology and Medicine·Jingfei Cheng, Joseph P Grande

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