TARGIT-E(lderly)--prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer.

BMC Cancer
Christian NeumaierWenz Frederik

Abstract

Patients ≥ 70 years with small, low-risk breast cancer who are operated but not irradiated how local relapse rates around 4% after 4 years. With adjuvant whole breast radiotherapy (WBRT) the local relapse rate drops to 1% after 4 years under Tamoxifen. It has been demonstrated that the efficacy of radiotherapy of the tumor bed only in a selected group can be non-inferior to WBRT. This prospective, multicentric single arm phase II study is based on the protocol of the international TARGIT-A study. The TARGIT-E study should confirm the efficacy of a single dose of intraoperative radiotherapy (IORT) in a well selected group of elderly patients with small breast cancer and absence of risk factors. Patients will receive IORT (20 Gy with Intrabeam system/Carl Zeiss) during breast conserving surgery. In presence of risk factors postoperative WBRT will be added to complete the radiotherapeutic treatment according to international guidelines. Endpoints are the local relapse rate (within 2 cm of the tumor bed), ipsilateral in breast relapse, cancer-specific and overall survival and contralateral breast cancer as well as documentation of quality of life and cosmetic outcome.The expected local relapse rates are 0.5/1/1.5% after 2.5/5/7.5 y...Continue Reading

References

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Citations

Jan 30, 2014·Journal of Geriatric Oncology·Noam VanderWaldeHyman Muss
Sep 3, 2014·International Journal of Breast Cancer·Harriet B Eldredge-HindyNicole L Simone
Nov 19, 2013·Zeitschrift für medizinische Physik·Frank SchneiderFrederik Wenz
Oct 20, 2015·European Journal of Radiology·Aurélie Jalaguier-CoudrayM Resbeut
May 28, 2014·Journal of Surgical Oncology·Rachel N GobleChristine Laronga
Aug 20, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stefan StefanovicBenjamin Tuschy
Feb 24, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yasser Abo-MadyanFrederik Wenz
Jan 3, 2021·Current Oncology Reports·Ammoren DohmRonica H Nanda
Apr 9, 2021·International Journal of Radiation Oncology, Biology, Physics·Jean-Michel Hannoun-LéviMarie-Eve Chand

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Methods Mentioned

BETA
biopsy

Software Mentioned

TARGIT

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