Tas, a retrotransposon from the parasitic nematode Ascaris lumbricoides

Gene
H FelderF Müller

Abstract

The cloned retrotransposon Tas OE3 from the genome of the parasitic nematode Ascaris lumbricoides was completely sequenced. The element is flanked by long terminal repeats (LTR) and contains three distinct regions encoding putative proteins typical for retroid elements. The first region, ORF1, encodes a putative Gag protein including a 'Leu zipper', a nucleic acid binding motif, as well as an aspartic protease domain. The second region contains an incomplete ORF (ORF2) with sequence similarities to known retroviral reverse transcriptases (RT), ribonucleases H and integrases. A third ORF, which is located adjacent to the 3' LTR, might encode an env-like protein. Based on amino-acid sequence analysis of the RT domain, Tas falls into a new subgroup of LTR-containing retrotransposons.

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Citations

Dec 2, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Hiroko AwataHiroshi Endoh
Mar 25, 2000·International Journal for Parasitology·F Müller, H Tobler
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Feb 6, 2013·Genome Génome / Conseil National De Recherches Canada·Christian McKinnon, Guy Drouin
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Jul 5, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hitoshi Nakayashiki
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