Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation

Scientific Reports
Yaniv Cohen, Donald A Wilson

Abstract

Cerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explored functional lateralization in both primary olfactory cortex - a region critical for odor memory and perception- and orbitofrontal cortex (OFC) - a region involved in reversal learning- in rats performing an odor learning and reversal task. We find significant asymmetry in both olfactory and orbitofrontal cortical odor-evoked activity, which is expressed in a performance- and task-dependent manner. The emergence of learning-dependent asymmetry during reversal learning was associated with decreased functional connectivity both between the bilateral OFC and between the OFC-olfactory cortex. The results suggest an inter-hemispheric asymmetry and olfactory cortical functional separation that may allow multiple, specialized processing circuits to emerge during a reversal task requiring behavioral flexibility.

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Citations

Mar 3, 2020·International Journal of Neural Systems·Huirang HouQinghao Meng
Jan 1, 2020·Scientific Reports·Nicolas Fourcaud-TrocméNathalie Buonviso
Dec 7, 2018·Brain Structure & Function·Emmanuelle CourtiolDonald A Wilson
Oct 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alizée Lopez-PersemJérôme Sallet
Oct 2, 2021·Brain Structure & Function·Matthias CaveliusAnne Didier

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