Task-evoked functional connectivity does not explain functional connectivity differences between rest and task conditions

Human Brain Mapping
Lauren K LynchZhongming Liu

Abstract

During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task-evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task-evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory or motor cortices. Our results suggest that task-evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter-regional correlation.

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Citations

Jul 20, 2019·Human Brain Mapping·Amy M JimenezMichael F Green
Nov 26, 2019·Journal of Neuroscience Research·Manon EddeSandra Chanraud
Dec 24, 2020·Neurorehabilitation and Neural Repair·E Susan DuncanSteven L Small
Jun 17, 2021·Communications Biology·Soren Wainio-ThebergeGeorg Northoff
Aug 24, 2021·Current Opinion in Biomedical Engineering·Yizhen ZhangZhongming Liu
Dec 4, 2021·Experimental Brain Research·Kaleb VinehoutBrian D Schmit

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