PMID: 11897992Mar 19, 2002Paper

Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions

The Journal of Allergy and Clinical Immunology
N Franklin AdkinsonHealth and Environmental Sciences Institute Task Force

Abstract

Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical practice, drug development, and public health. However, research to understand IDHR mechanisms and to develop diagnostic and predictive tests has been limited. To stimulate more research, a task force with representatives from the key stakeholders (research clinicians, regulatory scientists, and immunotoxicologists from the pharmaceutical industry) was assembled to identify critical data gaps and opportunities and to make recommendations on how to overcome some of the barriers to IDHR research and address research needs. It is hoped that this report will act as a springboard for future discussions and progress toward increased funding and development of organizational structures for IDHR research.

Citations

Jan 15, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Janice K BushThomas Hassall
Aug 3, 2010·Journal of Korean Medical Science·Ji Woong JangTae-Bum Kim
Nov 6, 2012·Clinical and Translational Allergy·Nikolaos G PapadopoulosCezmi A Akdis
Jul 31, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mark F Bonfiglio, David M Weinstein
Jul 20, 2002·Current Opinion in Allergy and Clinical Immunology·Rebecca S Gruchalla
May 19, 2005·Toxicological Reviews·Helen V Ratajczak
Dec 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Hsin-Pin HoMaw-Rong Lee
Oct 30, 2008·Journal of Immunotoxicology·Thomas T KawabataN Franklin Adkinson
Nov 13, 2013·Expert Review of Clinical Immunology·Adriana ArizaMaría José Torres
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan NierkensRaymond Pieters
Apr 5, 2014·Allergy·P DemolyB Y- H Thong
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M RubioP Demoly
Aug 13, 2015·British Journal of Pharmacology·J SzebeniJ Folkersen
Sep 9, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Diana Lucía Silva EspinosaCarlos Daniel Serrano Reyes
Aug 28, 2004·Clinics in Chest Medicine·Philippe CamusPascal Foucher
Mar 4, 2008·The Journal of Allergy and Clinical Immunology·Kathrin M Cresswell, Aziz Sheikh

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