Task-induced brain state manipulation improves prediction of individual traits

Nature Communications
Abigail S GreeneR Todd Constable

Abstract

Recent work has begun to relate individual differences in brain functional organization to human behaviors and cognition, but the best brain state to reveal such relationships remains an open question. In two large, independent data sets, we here show that cognitive tasks amplify trait-relevant individual differences in patterns of functional connectivity, such that predictive models built from task fMRI data outperform models built from resting-state fMRI data. Further, certain tasks consistently yield better predictions of fluid intelligence than others, and the task that generates the best-performing models varies by sex. By considering task-induced brain state and sex, the best-performing model explains over 20% of the variance in fluid intelligence scores, as compared to <6% of variance explained by rest-based models. This suggests that identifying and inducing the right brain state in a given group can better reveal brain-behavior relationships, motivating a paradigm shift from rest- to task-based functional connectivity analyses.

References

Jul 21, 2000·Science·J DuncanH Emslie
Feb 20, 2003·Nature Neuroscience·Jeremy R GrayTodd S Braver
Aug 25, 2004·NeuroImage·Richard J HaierMichael T Alkire
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 23, 2006·Nature Reviews. Neuroscience·John-Dylan Haynes, Geraint Rees
Aug 11, 2006·Trends in Cognitive Sciences·Kenneth A NormanJames V Haxby
Jul 28, 2007·The Behavioral and Brain Sciences·Rex E Jung, Richard J Haier
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu Yong ChoiKun Ho Lee
Mar 21, 2009·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Xenophon PapademetrisJames S Duncan
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Uri HassonSteven L Small
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
May 18, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn P van den Heuvel, Hilleke E Hulshoff Pol
Jan 21, 2011·Neuroinformatics·Alark JoshiXenophon Papademetris
Jul 20, 2011·Human Brain Mapping·R Cameron CraddockHelen S Mayberg
Jan 1, 2011·Brain Connectivity·Karl J Friston
Feb 9, 2013·Brain Structure & Function·Aron K BarbeyJordan Grafman
May 2, 2013·NeuroImage·F Xavier CastellanosMichael P Milham
May 15, 2013·NeuroImage·Matthew F GlasserUNKNOWN WU-Minn HCP Consortium
May 21, 2013·NeuroImage·Deanna M BarchUNKNOWN WU-Minn HCP Consortium
May 21, 2013·NeuroImage·David C Van EssenUNKNOWN WU-Minn HCP Consortium
May 25, 2013·NeuroImage·Stephen M SmithUNKNOWN WU-Minn HCP Consortium
May 25, 2013·NeuroImage·Kamil UğurbilUNKNOWN WU-Minn HCP Consortium
May 28, 2013·NeuroImage·R Matthew HutchisonCatie Chang
Jun 20, 2013·Biological Psychiatry·Robert Whelan, Hugh Garavan
Jun 27, 2013·Nature Neuroscience·Randy L BucknerB T Thomas Yeo
Aug 8, 2013·NeuroImage·Theodore D SatterthwaiteRaquel E Gur
Nov 2, 2013·Science·Nicholas B Turk-Browne
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols
Mar 22, 2014·Cerebral Cortex·Theodore D SatterthwaiteRuben C Gur
Jul 6, 2014·Neuron·Michael W ColeSteven E Petersen
Sep 3, 2014·Neuropsychology·Tyler M MooreRuben C Gur
Dec 17, 2014·PloS One·Evan S LutkenhoffMartin M Monti
Dec 20, 2014·Human Brain Mapping·Dustin ScheinostR Todd Constable
Jan 9, 2015·Neuron·John D E GabrieliSusan Whitfield-Gabrieli
Mar 25, 2015·Journal of Cognitive Neuroscience·John D MedagliaDanielle S Bassett

❮ Previous
Next ❯

Citations

Oct 2, 2019·The American Journal of Psychiatry·Raquel E Gur, Ruben C Gur
Jul 11, 2019·Science China. Life Sciences·Dongya WuTianzi Jiang
Jul 16, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Corey HorienDustin Scheinost
Sep 13, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jingwen JinAprajita Mohanty
Nov 14, 2019·Molecular Psychiatry·Sarah D LichensteinSarah W Yip
May 23, 2020·Social Cognitive and Affective Neuroscience·Gabriella M AlvarezKeely A Muscatell
May 26, 2020·Human Brain Mapping·Dardo Tomasi, Nora D Volkow
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Monica D RosenbergMarvin M Chun
Apr 9, 2020·Frontiers in Neuroscience·Peter SörösKarsten Witt
Sep 5, 2020·Network Neuroscience·Deniz VatanseverJonathan Smallwood
Dec 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Graham L BaumTheodore D Satterthwaite
Mar 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Recep A OzdemirEmiliano Santarnecchi
Jul 23, 2020·Brain Structure & Function·Kirsten HilgerChristian J Fiebach
Dec 9, 2020·Nature Human Behaviour·Corey HorienDustin Scheinost
Jan 11, 2021·Current Opinion in Psychology·Maurizio Sicorello, Christian Schmahl
Oct 26, 2020·NeuroImage·Zhiting RenJiang Qiu
Jan 16, 2021·Cerebral Cortex·Aman TaxaliChandra Sripada
Jul 24, 2020·NeuroImage·Kausar AbbasJoaquín Goñi
Jan 15, 2021·Translational Psychiatry·Zhenfu WenMohammed R Milad
Jan 23, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dustin ScheinostWan-Ling Tseng
Sep 2, 2020·NeuroImage·Mengxia GaoTatia M C Lee
Nov 13, 2020·Developmental Cognitive Neuroscience·Kristina M RapuanoB J Casey
Jan 30, 2021·Cerebral Cortex·Zhihao WangPengfei Xu
Feb 15, 2020·Trends in Cognitive Sciences·Noa HerzMoshe Bar

❮ Previous
Next ❯

Software Mentioned

Matlab
R
FMRIB Software Library ( FSL )
BioImage Suite
CPM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.