Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions

Brain Structure & Function
Xin DiBharat B Biswal

Abstract

Understanding functional connectivity of the amygdala with other brain regions, especially task modulated connectivity, is a critical step toward understanding the role of the amygdala in emotional processes and the interactions between emotion and cognition. The present study performed coordinate-based meta-analysis on studies of task modulated connectivity of the amygdala which used psychophysiological interaction (PPI) analysis. We first analyzed 49 PPI studies on different types of tasks using activation likelihood estimation (ALE) meta-analysis. Widespread cortical and subcortical regions showed consistent task modulated connectivity with the amygdala, including the medial frontal cortex, bilateral insula, anterior cingulate, fusiform gyrus, parahippocampal gyrus, thalamus, and basal ganglia. These regions were in general overlapped with those showed coactivations with the amygdala, suggesting that these regions and amygdala are not only activated together, but also show different levels of interactions during tasks. Further analyses with subsets of PPI studies revealed task specific functional connectivities with the amygdala that were modulated by fear processing, face processing, and emotion regulation. These results su...Continue Reading

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Citations

May 19, 2017·Cerebral Cortex·Daniel Alcalá-LópezDanilo Bzdok
Oct 11, 2017·Social Cognitive and Affective Neuroscience·Sarah J KannHoi-Chung Leung
May 27, 2020·Annual Review of Developmental Psychology·Katie A McLaughlinDebbie Bitrán
Apr 28, 2018·Cognitive, Affective & Behavioral Neuroscience·Damien BreversChris Baeken
Jul 14, 2017·Scientific Reports·Indrajeet PatilGiorgia Silani
Jan 30, 2018·Frontiers in Psychology·Yangmei LuoXiting Huang
May 2, 2020·Brain Structure & Function·Hang YangBharat Biswal
Nov 5, 2020·Psychological Medicine·Wei LeiJing Chen
Feb 28, 2021·Developmental Cognitive Neuroscience·Caroline P HoyniakSusan B Perlman
Jul 1, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Chuanji GaoSvetlana V Shinkareva
Oct 13, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jeffrey M SpielbergAmit Anand

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