Task-related hemodynamic responses are modulated by reward and task engagement

PLoS Biology
Mariana M B CardosoAniruddha Das

Abstract

Hemodynamic recordings from visual cortex contain powerful endogenous task-related responses that may reflect task-related arousal, or "task engagement" distinct from attention. We tested this hypothesis with hemodynamic measurements (intrinsic-signal optical imaging) from monkey primary visual cortex (V1) while the animals' engagement in a periodic fixation task over several hours was varied through reward size and as animals took breaks. With higher rewards, animals appeared more task-engaged; task-related responses were more temporally precise at the task period (approximately 10-20 seconds) and modestly stronger. The 2-5 minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these reversed with ramp-like increases during low reward. The blood volume increased even more sharply when the animal shut his eyes and disengaged completely from the task (5-10 minutes). We propose a mechanism that controls vascular tone, likely along with local neural responses in a manner that reflects task engagement over the full range of timescales tested.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleL G Sharpe
Feb 1, 1991·Journal of Neuroscience Methods·E H Ratzlaff, A Grinvald
Jan 1, 1969·Journal of Experimental Psychology·B TurskyD Kahneman
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·D C SomersR B Tootell
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S P GandhiG M Boynton
Apr 9, 1999·Nature Neuroscience·L S KrimerP S Goldman-Rakic
May 18, 1999·Vision Research·G M BoyntonD J Heeger
Oct 19, 1999·Human Brain Mapping·A M Dale
Dec 29, 2000·Physics in Medicine and Biology·M KohlU Dirnagl
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
Jul 27, 2001·Journal of Endodontics·A M LepinskiW R Bowles
May 15, 2002·Journal of Neuroscience Methods·Amos Arieli, Amiram Grinvald
Oct 11, 2002·Nature·Geoffrey M Ghose, John H R Maunsell
Nov 9, 2002·Journal of Neurophysiology·Daniel S Marcus, David C Van Essen
May 27, 2003·Neuron·Valery A Kalatsky, Michael P Stryker
Aug 15, 2003·Journal of Neurophysiology·Gordon L ShulmanMaurizio Corbetta
Sep 2, 1959·The Journal of Physiology·D H HUBEL
Jul 16, 2004·Journal of Neurophysiology·John T SerencesEdward Awh
Sep 28, 2004·Journal of Applied Physiology·M J CarringtonJ Trinder
Aug 17, 2005·Neuron·Justin L GardnerKang Cheng
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carrie J McAdams, R Clay Reid
Apr 4, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B S OkenS M Elsas
Sep 15, 2006·Journal of Neurophysiology·Michael A SilverDavid J Heeger
Oct 13, 2006·Nature·Claire M PeppiattDavid Attwell
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mitsuhiro FukudaSeong-Gi Kim
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chad M SylvesterMaurizio Corbetta
Jun 27, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chad M SylvesterGordon L Shulman
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Burkhard PlegerRaymond J Dolan

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Citations

Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aniruddha DasPatrick J Drew
Dec 5, 2020·Nature Communications·Antoine BergelIvan Cohen
Jun 15, 2021·PLoS Computational Biology·Ali-Kemal AydinDavide Boido
Jul 16, 2021·PLoS Biology·Qingguang ZhangPatrick J Drew
Dec 15, 2021·PLoS Computational Biology·Michael R TranerIlya E Monosov

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