DOI: 10.1101/463042Nov 5, 2018Paper

Task-Related Hemodynamic Responses Are Modulated by Reward and Task-engagement

BioRxiv : the Preprint Server for Biology
Mariana M B CardosoAniruddha Das


Hemodynamic recordings from visual cortex contain powerful endogenous task-related responses that may reflect task-engagement distinct from attention. We tested this hypothesis with hemodynamic measurements (intrinsic-signal optical imaging) from monkey V1, while the animals’ engagement in a periodic fixation task over several hours was varied though reward size, and as animals took breaks. With higher rewards, animals appeared more task-engaged; task-related responses were more temporally precise at the task period (~ 10-20 seconds), and modestly stronger. Surprisingly, 2-5-minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these reversed with ramp-like increases during low reward. The blood volume increased even more sharply when the animal shut his eyes and disengaged completely from the task (5-10 minutes). We propose a mechanism that controls vascular tone, likely along with local neural responses, with phasic and tonic components tied to task-engagement.

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.