Abstract
The presumed involvement of the prefrontal cortex in the pathogenesis of obsessive-compulsive disorder (OCD) has fueled growing interest in cognitive paradigms with a putative sensitivity to this brain region. Measures of inhibition and executive functioning are thought to be promising in this regard. To our knowledge, this is the first study that has investigated task switching in OCD captures an important aspect of a paradigm that executive control, namely the preparation for an upcoming task. It was speculated that task switching costs would be enhanced in OCD patients, reflecting a fundamental deficit to quickly control the stream of thoughts. In addition, the paradigm allowed the measurement of backward inhibition, that is the time costs afforded for the re-engagement of a previously irrelevant task. A sample of 40 OCD patients, 20 psychiatric controls with anxiety disorders other than OCD as well as 20 healthy controls was investigated. Contrary to expectation, task switching costs were not elevated in OCD patients. Although anxiety control patients failed to display robust backward inhibition, group comparisons did not reach significance. Implications for future research are discussed.
Citations
Feb 14, 2012·Psychological Research·James A GrangeGeorge Houghton
May 25, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Todd A SmithermanJudith R O'Jile
May 15, 2012·Psychological Medicine·S Morein-ZamirT W Robbins
May 3, 2013·PloS One·Peter L RemijnseDick J Veltman
May 28, 2013·Shinrigaku kenkyu : The Japanese journal of psychology·Megumi WatanabeAki Matsumoto
Nov 7, 2015·Psychological Medicine·S Morein-ZamirT W Robbins
Aug 16, 2011·Psychiatry Research·Steffen MoritzKarl-Heinz T Bäuml
Jun 29, 2010·Psychiatry Research·Nachshon MeiranBoris Nemets
Mar 15, 2006·Brain Research Bulletin·Min BaoDa-Ren Zhang
Apr 5, 2016·Acta Psychologica·Francesca M BranziAlbert Costa
Sep 5, 2015·Journal of Clinical and Experimental Neuropsychology·Esther Vierck
Jun 19, 2013·NeuroImage·Camille PiguetPatrik Vuilleumier
Sep 1, 2009·Journal of Behavior Therapy and Experimental Psychiatry·Steffen MoritzLena Jelinek
Sep 23, 2016·The Quarterly Journal of Experimental Psychology : QJEP·Agnieszka W Kowalczyk, James A Grange
Nov 14, 2015·PloS One·Francesca FotiFabio Ferlazzo
Apr 8, 2017·Journal of Cognitive Neuroscience·Angie A KehagiaTrevor W Robbins
Apr 1, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nicole WolffChristian Beste
Jun 10, 2019·Psychological Research·Agnieszka W Kowalczyk, James A Grange
Jul 18, 2016·Current Psychiatry Reports·Nabil BenzinaAntoine Pelissolo
Apr 30, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nicole WolffChristian Beste
Nov 19, 2018·Acta Psychologica·James A GrangeAlison Walker
Feb 27, 2021·Psychiatry Research·Lindsay M FruehaufMichael J Larson
Apr 15, 2021·PeerJ·Li ZhaoYonghui Wang
Apr 21, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Franziska GillerChristian Beste