Taste bud leptin: sweet dampened at initiation site

Chemical Senses
Susan P Travers, Marion E Frank

Abstract

The intriguing observation that leptin decreases sweet-evoked peripheral gustatory responses has aroused much interest (Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y. 2000. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci U S A. 97(20):11044-11049.) due to its implied importance in controlling appetite. The effects of this anorexic hormone, however, appear more conditional than originally believed. In this issue of Chemical Senses, a careful study by Glendinning and colleagues, find no effects of leptin on sweet-evoked chorda tympani responses, whereas an equally careful study by Meredith and colleagues, find decreased release of ATP and increased release of 5-HT from taste buds in response to sweet stimuli.

References

Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KawaiY Ninomiya
Dec 16, 2005·Nature·Karel TalaveraBernd Nilius
Jul 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andras HajnalRobert N Cooney
Dec 25, 2012·Seminars in Cell & Developmental Biology·Stephen D Roper
Jan 26, 2013·Seminars in Cell & Developmental Biology·Cedrick D DotsonSteven D Munger
Oct 1, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Huan CaiBronwen Martin
Sep 19, 2014·The Journal of Endocrinology·Margaret B Allison, Martin G Myers

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Citations

May 21, 2020·Diabetes & Metabolism Journal·Kerstin RohdeMatthias Blüher

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