Taste cell formation does not require gustatory and somatosensory innervation.

Neuroscience Letters
Akira ItoChristopher Nosrat

Abstract

Dependency of taste buds and taste papillae on innervation has been debated for a long time. Previous research showed neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), play an important role for the establishment of the lingual gustatory and somatosensory innervation. BDNF null mutant mice showed severe deficits in gustatory innervation and loss of taste buds while NT-3 null mutation reduced lingual somatosensory innervation to tongue papillae. These results proved BDNF or NT-3 null mutations affected different sensory modalities (i.e. gustatory and somatosensory, respectively). In this study, we analyzed taste bud development in BDNFxNT-3 double knockout mice to examine the relationship between taste bud development and gustatory/somatosensory innervation. Our results demonstrate that, at the initial stage, before nerve fibers reached the appropriate areas in the papilla, taste bud formation did not require innervation. However, at the synaptogenic stage, after nerve fibers ramified into the apical epithelium, innervation was required and played an essential role in the development of taste buds/papillae.

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Citations

Nov 28, 2012·Seminars in Cell & Developmental Biology·Marika Kapsimali, Linda A Barlow
Oct 8, 2011·Journal of Anatomy·Yuko SuzukiKiyoshi Kawakami
Aug 24, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gareth J FraserJ Todd Streelman
Sep 13, 2015·Developmental Neurobiology·Jacquelyn M OmelianSuzanne I Sollars
May 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tadashi Okubo, Shinji Takada
Jan 1, 2014·Developmental Biology·Tao Huang, Robin F Krimm
Apr 9, 2015·Frontiers in Aging Neuroscience·Jennifer Kersigo, Bernd Fritzsch
Oct 22, 2016·In Vitro Cellular & Developmental Biology. Animal·Kotaro Honda, Yasuhiro Tomooka
Jan 11, 2019·Genesis : the Journal of Genetics and Development·Sonia Sudiwala, Sarah M Knox
Oct 2, 2019·Genesis : the Journal of Genetics and Development·Mohamed IshanHong-Xiang Liu
Oct 2, 2019·ELife·Di FanJean-François Brunet

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