Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Aleksandra AmelianKatarzyna Winnicka

Abstract

Orally disintegrating tablets and oral lyophilisates are novel attractive dosage forms that disintegrate or dissolve in the buccal cavity within seconds without necessity of drinking. The major limitation in designing of these dosage forms is unpleasant taste of the drug substance. Cetirizine dihydrochloride is a H1-antihistamine substance indicated for the treatment of allergy. It is characterized by extremely bitter taste, therefore in order to deliver cetirizine dihydrochloride using orodispersible formulations, effective taste-masking is required. The aim of this study was to investigate whether microparticles containing cetirizine dihydrochloride could be successfully used to formulate orally disintegrating tablets by direct compression method and oral lyophilisates by freeze-drying process. Taste masking of cetirizine dihydrochloride was achieved by the spray-drying technique using Eudragit® E PO as the drug agent carrier. Based on the preliminary studies, optimal compositions of microparticles, tablets and lyophilisates were chosen. Obtained dosage forms were characterized for drug content, disintegration time and mechanical properties. In order to determine whether the microparticles subjected to direct compression and ...Continue Reading

Citations

Nov 5, 2019·Pharmaceutical Development and Technology·Mellisa T R ChikukwaSandile M M Khamanga
Jan 24, 2020·Current Pharmaceutical Design·Phuong H L Tran, Thao T D Tran
Dec 5, 2020·Pharmaceutical Development and Technology·Marina Delanni Vitória GuedesIrene Clemes Kulkamp Guerreiro
Jul 2, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Katarzyna Wasilewska, Katarzyna Winnicka

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Methods Mentioned

BETA
scanning electron microscopy
PCA

Software Mentioned

Chemstation
Origin
MatLab

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