Taste Receptors: New Players in Sperm Biology

International Journal of Molecular Sciences
Alice LuddiPaola Piomboni

Abstract

Taste receptors were first described as sensory receptors located on the tongue, where they are expressed in small clusters of specialized epithelial cells. However, more studies were published in recent years pointing to an expression of these proteins not only in the oral cavity but throughout the body and thus to a physiological role beyond the tongue. The recent observation that taste receptors and components of the coupled taste transduction cascade are also expressed during the different phases of spermatogenesis as well as in mature spermatozoa from mouse to humans and the overlap between the ligand spectrum of taste receptors with compounds in the male and female reproductive organs makes it reasonable to assume that sperm "taste" these different cues in their natural microenvironments. This assumption is assisted by the recent observations of a reproductive phenotype of different mouse lines carrying a targeted deletion of a taste receptor gene as well as the finding of a significant correlation between human male infertility and some polymorphisms in taste receptors genes. In this review, we depict recent findings on the role of taste receptors in male fertility, especially focusing on their possible involvement in me...Continue Reading

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Citations

May 3, 2020·International Journal of Molecular Sciences·Fernando J Peña
Jan 23, 2020·Journal of Clinical Medicine·Laura GoverniniPaola Piomboni
Apr 16, 2020·International Journal of Molecular Sciences·Michaela FrolikovaKaterina Komrskova
Oct 20, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Clelia GaspariniJonathan P Evans
Feb 12, 2021·Animals : an Open Access Journal From MDPI·Ting GongQi Mu

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Methods Mentioned

BETA
gene-knockout
contraception

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