Taste responses of neurons of the hamster solitary nucleus are enhanced by lateral hypothalamic stimulation

Journal of Neurophysiology
Young K ChoD V Smith

Abstract

Gustatory responses in the brain stem are modifiable by several physiological factors, including blood insulin and glucose, intraduodenal lipids, gastric distension, and learning, although the neural substrates for these modulatory effects are not known. Stimulation of the lateral hypothalamus (LH) produces increases in food intake and alterations in taste preference behavior, whereas damage to this area has opposite effects. In the present study, we investigated the effects of LH stimulation on the neural activity of taste-responsive cells in the nucleus of the solitary tract (NST) of the hamster. Bipolar stimulating electrodes were bilaterally implanted in the LH, and the responses of 99 neurons in the NST, which were first characterized for their taste sensitivities, were tested for their response to both ipsilateral and contralateral LH stimulation. Half of the taste-responsive cells in the NST (49/99) were modulated by LH stimulation. Contralateral stimulation was more often effective (41 cells) than ipsilateral (13 cells) and always excitatory; 10 cells were excited bilaterally. Six cells were inhibited by ipsilateral stimulation. A subset of these cells (n = 13) was examined for the effects of microinjection of DL-homocy...Continue Reading

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Citations

Jun 6, 2008·Journal of Neurophysiology·Young K Cho, Cheng-Shu Li
May 7, 2010·Journal of Neurophysiology·Andrew M RosenPatricia M Di Lorenzo
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria D HurtadoSergei Zolotukhin
Aug 19, 2009·Annals of the New York Academy of Sciences·Andras HajnalPeter Kovacs
Mar 3, 2006·Behavioral and Cognitive Neuroscience Reviews·Alan C Spector, Susan P Travers
Feb 20, 2004·Journal of Neurophysiology·Ken'ichi TokitaTakashi Yamamoto
May 6, 2005·Chemical Senses·David V SmithCheng-Shu Li
Sep 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cheng-Shu Li, Young K Cho
Mar 7, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Limin MaoCheng-Shu Li
Aug 6, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wei HuangXiao-Jun Wu
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cheng-Shu LiYoung K Cho
Jan 23, 2016·Journal of Neurophysiology·Madelyn A Baez-SantiagoDonald B Katz
Feb 20, 2003·Brain Research·Cheng-Shu LiDavid V Smith
Oct 27, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Cheng-Shu LiYoung-Kyung Cho

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