Taste responsiveness to sweeteners is resistant to elevations in plasma leptin

Chemical Senses
John I GlendinningSteven D Munger

Abstract

There is uncertainty about the relationship between plasma leptin and sweet taste in mice. Whereas 2 studies have reported that elevations in plasma leptin diminish responsiveness to sweeteners, another found that they enhanced responsiveness to sucrose. We evaluated the impact of plasma leptin on sweet taste in C57BL/6J (B6) and leptin-deficient ob/ob mice. Although mice expressed the long-form leptin receptor (LepRb) selectively in Type 2 taste cells, leptin failed to activate a critical leptin-signaling protein, STAT3, in taste cells. Similarly, we did not observe any impact of intraperitoneal (i.p.) leptin treatment on chorda tympani nerve responses to sweeteners in B6 or ob/ob mice. Finally, there was no effect of leptin treatment on initial licking responses to several sucrose concentrations in B6 mice. We confirmed that basal plasma leptin levels did not exceed 10ng/mL, regardless of time of day, physiological state, or body weight, suggesting that taste cell LepRb were not desensitized to leptin in our studies. Furthermore, i.p. leptin injections produced plasma leptin levels that exceeded those previously reported to exert taste effects. We conclude that any effect of plasma leptin on taste responsiveness to sweeteners...Continue Reading

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Citations

May 14, 2016·Physiology & Behavior·Gary K Beauchamp
Feb 4, 2019·Journal of Neuroendocrinology·Maik Behrens, Wolfgang Meyerhof
Aug 16, 2017·Journal of Nutrition and Metabolism·Lénia RodriguesElsa Lamy
Sep 4, 2019·Metabolic Syndrome and Related Disorders·Burcin UygunSinan Cavun
Dec 16, 2020·Journal of Neurochemistry·Ryusuke YoshidaYuzo Ninomiya

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