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Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells

Blood

Mar 29, 2013

Nayoung KimAnna Aldovini

Abstract

As a result of its interaction with transcription factors, HIV type 1 (HIV-1) Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon (IFN)-stimulated genes (ISGs) in the absence of IFNs. We investi...read more

Mentioned in this Paper

HIV Infections
HIV-1
IRF7 gene
STAT1 protein, human
MAP2K3 protein, human
MAP2K6 protein, human
MAPK14 protein, human
MAP2K3 gene
Metabolic Inhibition
Interferons
1
27
Paper Details
References
  • References38
  • Citations8
1234
  • References38
  • Citations8
1

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Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells

Blood

Mar 29, 2013

Nayoung KimAnna Aldovini

PMID: 23535064

DOI: 10.1182/blood-2012-10-461566

Abstract

As a result of its interaction with transcription factors, HIV type 1 (HIV-1) Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon (IFN)-stimulated genes (ISGs) in the absence of IFNs. We investi...read more

Mentioned in this Paper

HIV Infections
HIV-1
IRF7 gene
STAT1 protein, human
MAP2K3 protein, human
MAP2K6 protein, human
MAPK14 protein, human
MAP2K3 gene
Metabolic Inhibition
Interferons
1
27

Similar Papers Found In These Feeds

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Paper Details
References
  • References38
  • Citations8
1234
  • References38
  • Citations8
1
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