PMID: 11906263Mar 22, 2002Paper

Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles

Bioconjugate Chemistry
Patrick WunderbaldingerRalph Weissleder

Abstract

Superparamagnetic nanoparticles have a number of important biomedical applications, serving as MR contrast agents for imaging specific molecular targets, as reagents for cell labeling and cell tracking, and for the isolation of specific classes of cells. We have determined the physical and biological properties of MION-47 and amino-CLIO, nanoparticles which serve as precursors for the synthesis of targeted MR contrast agents, and Tat-CLIO, a nanoparticle used as a cell labeling reagent. Blood half-lives for MION-47 and amino-CLIO were 682 +/- 34 and 655 +/- 37 min, respectively. The attachment of 9.7 tat peptides per crystal to amino-CLIO resulted in a reduction in blood half-life to 47 +/- 6 min. MION-47, amino-CLIO, and Tat-CLIO were present in highest concentrations in liver and spleen and lymph nodes, where concentrations for all three nanoparticles ranged from 8.80 to 6.11% of injected dose per gram. Twenty-four hours after the intravenous injection of amino-CLIO, the nanoparticle was concentrated in cells surrounding hepatic blood vessels (endothelial and Kupffer cells), in a fashion similar to that obtained with other nanoparticle preparations. In contrast, Tat-CLIO was present as numerous discrete foci of intense fluore...Continue Reading

References

Nov 23, 2000·Bioconjugate Chemistry·D HögemannJ P Basilion
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·B E Van BeersA M Smith

❮ Previous
Next ❯

Citations

Mar 8, 2008·Basic Research in Cardiology·David E SosnovikRalph Weissleder
Jun 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kimberly A KellyRalph Weissleder
Jul 8, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lars StelterUlf Teichgräber
Mar 1, 2009·Journal of Cardiovascular Translational Research·Ernest V GromanDennis E Vaccaro
Dec 14, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gregory M LanzaSamuel A Wickline
Mar 6, 2003·Journal of Colloid and Interface Science·Junge LuYong Gao
Sep 6, 2003·Journal of Colloid and Interface Science·Jinda FanYong Gao
Aug 6, 2003·Current Opinion in Immunology·Robia G Pautler, Scott E Fraser
May 22, 2009·Bioconjugate Chemistry·Jason R McCarthyFarouc A Jaffer
Jul 20, 2004·Nature Biotechnology·Xiaohu GaoShuming Nie
Jul 25, 2008·Nature Clinical Practice. Cardiovascular Medicine·David E SosnovikRalph Weissleder
Feb 24, 2009·Nature Materials·Ji-Ho ParkMichael J Sailor
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kimberly A KellyRalph Weissleder
Aug 12, 2008·Topics in Magnetic Resonance Imaging : TMRI·David E Sosnovik
Nov 19, 2009·Circulation. Cardiovascular Imaging·David E SosnovikAnthony Rosenzweig
Jul 7, 2007·The AAPS Journal·Tarek M FahmyW Mark Saltzman
Aug 25, 2007·Nanomedicine·Jason R McCarthyRalph Weissleder
Sep 11, 2008·Radiology·Grigorios KorosoglouMatthias Stuber
May 16, 2014·Chemical Communications : Chem Comm·Nam-Young KangYoung-Tae Chang
Apr 20, 2011·Radiology·Amelie M LutzSanjiv S Gambhir
Oct 16, 2004·Molecular and Cellular Neurosciences·Gunnar P H Dietz, Mathias Bähr
Oct 13, 2006·Organic & Biomolecular Chemistry·Morag OliverMichael R Jorgensen
Jun 20, 2008·Organic & Biomolecular Chemistry·Kelly M StewartShana O Kelley
Nov 30, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Chao HuangEn-Tang Kang
Mar 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Thomas D SchladtWolfgang Tremel
Oct 11, 2013·Nanoscale·Roxanne HachaniNguyen Thi Kim Thanh
Apr 7, 2012·Chemical Society Reviews·Miriam ColomboWolfgang J Parak
Jul 31, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Luca Frullano, Thomas J Meade
Sep 23, 2006·Expert Opinion on Biological Therapy·Craig HalberstadtKen Gonsalves
Jan 12, 2011·Expert Opinion on Drug Delivery·Avnesh Kumari, Sudesh Kumar Yadav
Apr 25, 2007·Journal of Drug Targeting·Dwaine F Emerich, Christopher G Thanos
Jul 22, 2010·Expert Opinion on Drug Delivery·Mohammad Zaki AhmadRoop Krishen Khar
Feb 16, 2005·Expert Opinion on Biological Therapy·Dwaine F Emerich
Aug 3, 2014·Advanced Drug Delivery Reviews·Xiang LiThierry Vandamme
Jul 2, 2003·Expert Opinion on Biological Therapy·Dwaine F Emerich, Christopher G Thanos
Dec 2, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Sima MajidiAbolfazl Akbarzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.