Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

Journal of Virology
Todd M AllenDavid I Watkins

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

References

Feb 1, 1994·AIDS Research and Human Retroviruses·M G LewisG A Eddy
Jun 12, 1998·Nature Medicine·J N ReitterR C Desrosiers
Jul 27, 1999·Vaccine·A D OsterhausG Sutter
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·C D PauzaR C Gallo
Apr 3, 2001·Science·D Paydarfar, W J Schwartz
Nov 21, 2001·British Medical Bulletin·B KorberV Detours

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Citations

Sep 25, 2003·Vaccine·Joanne H van HarmelenCarolyn Williamson
Mar 19, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Max W RichardsonJay Rappaport
Jan 28, 2003·Trends in Immunology·Otto O Yang
Jun 7, 2008·Nature Medicine·David I WatkinsWayne C Koff
Sep 5, 2002·Nature Reviews. Immunology·Dennis R Burton
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Margherita RosatiGeorge N Pavlakis
Jun 24, 2004·The Journal of Experimental Medicine·Tetsuro MatanoYoshiyuki Nagai
Nov 17, 2004·The Journal of Experimental Medicine·Nicola A JonesPersephone Borrow
Apr 8, 2009·The Journal of Experimental Medicine·David A PriceDaniel C Douek
Oct 25, 2002·DNA and Cell Biology·Emanuele Fanales-BelasioBarbara Ensoli
Oct 25, 2002·DNA and Cell Biology·David H O'ConnorDavid I Watkins
Feb 18, 2004·DNA and Cell Biology·Max W RichardsonJay Rappaport
Mar 24, 2012·AIDS·Adrian B McDermott, Richard A Koup
Sep 26, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Panagiotis VagenasMelissa Robbiani
Dec 1, 2006·Journal of Virology·Chungwon ChungDavid I Watkins
Feb 14, 2003·Journal of Virology·Ilia TikhonovC David Pauza
Mar 23, 2006·Annual Review of Immunology·Andrew J McMichael
Sep 24, 2010·PloS One·Jeanette C ReeceStephen J Kent
Apr 22, 2008·Memórias do Instituto Oswaldo Cruz·David I Watkins
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael R BettsGuido Ferrari

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