Tau: A Common Denominator and Therapeutic Target for Neurodegenerative Disorders

Journal of Experimental Neuroscience
Alexander Maxan, Francesca Cicchetti

Abstract

There is compelling evidence that a number of neurodegenerative diseases share common pathogenic mechanisms. Better understanding these mechanisms will allow us to develop new therapeutic strategies. This commentary follows up on our recent findings that tau pathology can be found in healthy fetal tissue transplanted into the brain of patients with either Huntington or Parkinson disease. We will examine how tau appears to be shared in a number of different conditions and how its expression relates to cognitive decline and disease progression. We will further review pathogenic mechanisms and especially the relevance of the possible prion-like behavior of tau. We will conclude by discussing how all this work opens up novel therapeutic approaches to treating the cognitive impairments related to neurodegenerative diseases using a common strategy.

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Citations

Nov 21, 2019·Journal of Alzheimer's Disease : JAD·Neha Sawant, P Hemachandra Reddy
Nov 2, 2019·Neurobiology of Disease·Anne Messer, David C Butler
Dec 18, 2020·Frontiers in Neurology·Maria MasnataFrancesca Cicchetti
Feb 28, 2021·Journal of Neurochemistry·Santosh R D'Mello

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Methods Mentioned

BETA
transgenic
biosensor

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