Abstract
Trastuzumab (H)-based chemotherapy has been an active treatment in patients with HER2-positive breast cancer; however, primary and secondary resistance has occurred in patients treated with H alone or in combination with chemotherapy. Biomarkers were searched using tissue microarrays (TMA) in HER2-positive advanced breast cancer patients treated with H and paclitaxel (P) combination chemotherapy between October 2004 and August 2010. Tumor blocks were analyzed for Tau-protein, beta-III tubulin, PTEN, p27, IGF-1R, c-Met, CD44, and MUC4 by immunohistochemical (IHC) analysis. The correlation between IHC status and clinical outcomes, including response rate (RR), progression free survival (PFS), and overall survival (OS), was investigated. With a median follow-up duration of 54.1 months (range, 42.3-72.7 months), 65 patients received H + P chemotherapy. The overall RR was 63 % (95 % CI, 51-75 %), and seven patients (11 %) with high Tau/low PTEN expression showed a significantly lower RR (14 % vs. 69 %; p = 0.008). The odds ratio for a poor response was 13.3 (95 % CI, 1.5-119.0; p = 0.020). In addition, patients with high Tau/low PTEN showed a trend of poor survival in terms of PFS (6.6 months vs. 9.6 months, p = 0.052). Subsequent m...Continue Reading
References
Dec 22, 1999·Oncogene·Y LuG B Mills
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Mar 15, 2001·The New England Journal of Medicine·D J SlamonL Norton
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hong-Lin ChengNan-Haw Chow
Dec 21, 2002·International Journal of Clinical Oncology·Seiji TakahashiIkuo Fukuda
Aug 9, 2003·Cell Motility and the Cytoskeleton·Malathi HariFernando Cabral
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karine LlinaresMarie-Christine Copin
Aug 25, 2004·Cancer Cell·Yoichi NagataDihua Yu
Dec 25, 2004·Human Pathology·Chikako ShimizuYasuhiro Fujiwara
May 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel MartyJean-Marc Extra
May 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roman RouzierLajos Pusztai
Aug 17, 2005·Cell Cycle·P WagnerL Pusztai
Jan 13, 2006·British Journal of Cancer·T FujitaN Shimizu
Apr 29, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ZhangHuaxi Xu
May 25, 2006·British Journal of Cancer·K MimoriM Mori
Oct 6, 2006·Cancer Chemotherapy and Pharmacology·Pascal SèveJohn R Mackey
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabrice AndreLajos Pusztai
Apr 1, 2008·Biochimica Et Biophysica Acta·Christian F SingerGernot Hudelist
Jun 3, 2008·The Oncologist·Karen Bullock, Kimberly Blackwell
Jun 19, 2008·Breast Cancer Research : BCR·Gabriella HonethCecilia Hegardt
Nov 29, 2008·Cancer Chemotherapy and Pharmacology·Satoru TanakaNobuhiko Tanigawa
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paula R PohlmannRay Mernaugh
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly L BlackwellJoyce O'Shaughnessy
Sep 4, 2010·The American Journal of Pathology·Francisco J EstevaDihua Yu
May 20, 2011·Breast Cancer Research and Treatment·E RazisG Fountzilas
Jun 30, 2011·Cancer Chemotherapy and Pharmacology·Marta SmoterCezary Szczylik
Nov 2, 2011·Journal of the National Cancer Institute. Monographs·Valentina GuarneriPierfranco Conte
Dec 14, 2011·The New England Journal of Medicine·José BaselgaUNKNOWN CLEOPATRA Study Group
Dec 17, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J D JensenM Ewertz
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Oct 2, 2012·The New England Journal of Medicine·Sunil VermaUNKNOWN EMILIA Study Group
May 8, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edith A PerezMonica M Reinholz
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J D JensenM Ewertz
Citations
Sep 4, 2015·Medicinal Research Reviews·Songbo XieJun Zhou
Mar 3, 2017·PloS One·Daphne Gschwantler-KaulichChristian F Singer
Dec 1, 2017·International Journal of Molecular Sciences·Marilina García-Aranda, Maximino Redondo
Nov 25, 2017·Virchows Archiv : an International Journal of Pathology·Ben DavidsonMartin Tötsch
Feb 15, 2018·Cell & Bioscience·Yiyuan PanOuchen Wang
Nov 10, 2016·Oncotarget·Pengpeng XiaGuoqiang Zhu
Mar 3, 2019·BMC Cancer·Cornelia SchroederStefan Steurer
Dec 21, 2017·Reproductive Medicine and Biology·Aisa YamauchiYoshihito Yokoyama
Mar 11, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tuyelee DasAbhijit Dey
Apr 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria V Barbolina
Jul 25, 2021·International Journal of Molecular Sciences·Wan Nur Baitty Wan Mohd TajuddinRakesh Naidu