Tau and PTEN status as predictive markers for response to trastuzumab and paclitaxel in patients with HER2-positive breast cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Dong-Hoe KooKyung Hae Jung

Abstract

Trastuzumab (H)-based chemotherapy has been an active treatment in patients with HER2-positive breast cancer; however, primary and secondary resistance has occurred in patients treated with H alone or in combination with chemotherapy. Biomarkers were searched using tissue microarrays (TMA) in HER2-positive advanced breast cancer patients treated with H and paclitaxel (P) combination chemotherapy between October 2004 and August 2010. Tumor blocks were analyzed for Tau-protein, beta-III tubulin, PTEN, p27, IGF-1R, c-Met, CD44, and MUC4 by immunohistochemical (IHC) analysis. The correlation between IHC status and clinical outcomes, including response rate (RR), progression free survival (PFS), and overall survival (OS), was investigated. With a median follow-up duration of 54.1 months (range, 42.3-72.7 months), 65 patients received H + P chemotherapy. The overall RR was 63 % (95 % CI, 51-75 %), and seven patients (11 %) with high Tau/low PTEN expression showed a significantly lower RR (14 % vs. 69 %; p = 0.008). The odds ratio for a poor response was 13.3 (95 % CI, 1.5-119.0; p = 0.020). In addition, patients with high Tau/low PTEN showed a trend of poor survival in terms of PFS (6.6 months vs. 9.6 months, p = 0.052). Subsequent m...Continue Reading

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Dec 1, 2017·International Journal of Molecular Sciences·Marilina García-Aranda, Maximino Redondo
Nov 25, 2017·Virchows Archiv : an International Journal of Pathology·Ben DavidsonMartin Tötsch
Dec 21, 2017·Reproductive Medicine and Biology·Aisa YamauchiYoshihito Yokoyama
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Apr 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria V Barbolina

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