Tau at the Crossroads between Neurotoxicity and Neuroprotection

Neuron
Sarah L DeVos, Bradley T Hyman

Abstract

In contrast to the idea that tau phosphorylation is toxic, Ittner et al. (2016) recently showed that specific tau phosphorylation is neuroprotective, phenocopying tau ablation (DeVos et al., 2017), thus highlighting the complex tau biology that underlies neurotoxicity and neuroprotection.

References

Jul 27, 2012·The Journal of Biological Chemistry·Siddhartha Mondragón-RodríguezJannic Boehm
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah L DeVosTimothy M Miller
Nov 6, 2015·The EMBO Journal·Susanne WegmannBradley T Hyman
Nov 12, 2016·Nature Reviews. Cancer·Adam S SperlingBenjamin L Ebert
Jan 27, 2017·Science Translational Medicine·Sarah L DeVosTimothy M Miller

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