Tau Filaments and the Development of Positron Emission Tomography Tracers

Frontiers in Neurology
Michel GoedertN Sahara

Abstract

A pathological pathway leading from soluble, monomeric to insoluble, filamentous Tau, is believed to underlie human Tauopathies. Cases of frontotemporal dementia are caused by dominantly inherited mutations in MAPT, the Tau gene. They show that dysfunction of Tau protein is sufficient to cause neurodegeneration and dementia. Extrapolation to the more common sporadic Tauopathies leads one to conclude that the pathological pathway is central to the development of all cases of disease, even if there are multiple reasons for Tau assembly. These findings are conceptually similar to those reported for beta-amyloid, alpha-synuclein and prion protein. Here, we provide an overview of Tau filaments and their positron emission tomography ligands.

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Citations

Aug 31, 2018·Nature·Benjamin FalconMichel Goedert
Mar 9, 2019·Frontiers in Psychiatry·Mu-N LiuChing-Po Lin
Oct 31, 2018·Acta Neuropathologica Communications·Shannon L RisacherAndrew J Saykin
Nov 7, 2019·Frontiers in Neurology·Ali ShoeibiIrene Litvan
Jan 6, 2021·International Journal of Molecular Sciences·Sushil K MishraNaruhiko Sahara
Dec 6, 2019·Archives of Biochemistry and Biophysics·Vali AkbariReza Khodarahmi
Mar 11, 2021·ACS Chemical Neuroscience·Lindsay McMurrayFranklin I Aigbirhio
Mar 17, 2021·Acta Neuropathologica·Yang ShiMichel Goedert
Dec 24, 2020·Seminars in Nuclear Medicine·Leonie Beyer, Matthias Brendel
Aug 14, 2020·ACS Chemical Neuroscience·Raeann M DaltonJacob M Hooker
Apr 21, 2020·Chemical Science·Yanyan ZhaoFranklin I Aigbirhio
Sep 1, 2021·ACS Chemical Neuroscience·Yang ZhouHans Ågren

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Methods Mentioned

BETA
electron microscopy
acetylation
transgenic

Software Mentioned

AutoDock Vina
Pymol

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