Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease

Journal of Alzheimer's Disease : JAD
María Llorens-MartínFélix Hernández

Abstract

In the adult hippocampal dentate gyrus, newborn granule cells grow dendrites into the molecular layer and send axons into the CA3 region. Several molecular markers have been used to analyze production of these new neurons; however, no good markers for new axons have been described. Here we demonstrate that tau protein isoform with three microtubule binding domains (3R-Tau) is a marker of those axons following an antigen retrieval protocol. By using retrovirus-mediated GFP transduction, GFP can be detected in a period of 7-14 days after viral infection. We also provide a "proof of principle" demonstration of the power of that labeling showing modulation of 3R-Tau positive axons under physiological conditions (exercise and aging) as well as in a FTDP-17 neurodegenerative model and Alzheimer's disease models (mice overexpressing AβPPsw, ind or GSK3β). We conclude that 3R-Tau would be an efficient marker and a valuable tool to study new axons in adult neurogenesis as well as in neurodegenerative processes.

Citations

Feb 3, 2016·Frontiers in Neuroscience·María Llorens-MartínJesús Ávila
May 21, 2016·Frontiers in Neuroscience·Carolyn HollandsOrly Lazarov
Apr 8, 2017·Acta Neuropathologica·Tong GuoDiane P Hanger
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Catia M TeixeiraMaría Llorens-Martín
Dec 4, 2015·Nature Reviews. Neuroscience·Yipeng Wang, Eckhard Mandelkow
May 21, 2016·The EMBO Journal·Noemí Pallas-BazarraMaría Llorens-Martín
Feb 9, 2021·Mechanisms of Ageing and Development·Hang LiuYing Ma
Mar 2, 2021·Frontiers in Neurology·Sarah HoubenKunie Ando
May 7, 2020·Trends in Molecular Medicine·Norihito UemuraJohn Q Trojanowski

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