Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway

Aging Cell
Ao-Ji XieLing-Qiang Zhu

Abstract

Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced expression of human tau (hTau) in mouse cortical neurons impairs endocytosis by decreasing the level of the GTPase dynamin 1 via disruption of the miR-132-MeCP2 pathway; this process can also be detected in the brains of Alzheimer's patients and hTau mice. Our results provide evidence for a novel role of tau in the regulation of presynaptic function.

References

Jul 16, 2003·Journal of Neurochemistry·Cathy AndorferPeter Davies
Sep 13, 2015·Human Molecular Genetics·Pascal Y SmithSébastien S Hébert
Feb 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evgenia Salta, Bart De Strooper
May 12, 2017·Nature Communications·Lujia ZhouPatrik Verstreken

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Citations

May 17, 2019·Neural Plasticity·Chao-Chao YuLi-Hong Kong
Aug 23, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Subodh Kumar, P Hemachandra Reddy
Jan 6, 2021·Cell Death and Differentiation·Wen-Dai BaoLing-Qiang Zhu
Aug 15, 2021·Translational Neurodegeneration·Miao XuNan-Jie Xu

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Methods Mentioned

BETA
transgenic

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