PMID: 2501966Jan 1, 1989Paper

Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

Acta Neuropathologica
P DelaèreJ J Hauw

Abstract

Tau immunoreactivity was studied in temporal neocortex, area 22, in 15 cases with graded intellectual status and compared with the immunoreactivity observed with an antiserum against paired helical filaments (PHF) and with the density of amyloid revealed by thioflavin S. Samples came from women over 75 years either intellectually normal or affected by senile dementia of the Alzheimer type at various degrees of severity. Mental status had been prospectively assessed by the Blessed's test score. Anti-tau labelled a neuropil meshwork, the density of which increased with the severity of the disease. This meshwork was denser in layers II, III and V in the most affected cases. The number and the size of the tau-positive fibers within the senile plaques increased with the intellectual deficit. Senile plaques were more numerous in layers II and III and neurofibrillary tangles in layers III and V whatever the staining technique: tau or PHF immunocytochemistry, and thioflavin S. The densities of senile plaques and of neurofibrillary tangles (NFT) were correlated with the severity of the disease whatever the staining method. The three methods revealed a systematically different number of changes. This systematic difference could greatly i...Continue Reading

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Citations

Dec 24, 1997·Annals of Neurology·A L GuillozetM M Mesulam
Jan 1, 1989·Acta Neuropathologica·H M WisniewskiK S Kim
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·C BancherF Leblhuber
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Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J J HauwP Henry
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Jan 24, 2002·Neurobiology of Aging·Mark A LovellWilliam R Markesbery
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Aug 28, 2007·Annals of Neurology·Kristen L SagerJames J Lah

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