Feb 13, 2019

Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers

Brain : a Journal of Neurology
Brian A GordonTammie L S Benzinger

Abstract

Tauopathy is a hallmark pathology of Alzheimer's disease with a strong relationship with cognitive impairment. As such, understanding tau may be a key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid assays, but these do not provide information about where pathology is in the brain. The introduction of PET ligands that bind to paired helical filaments provides the ability to measure the amount and distribution of tau pathology. The heritability of the age of dementia onset tied to the specific mutations found in autosomal dominant Alzheimer's disease families provides an elegant model to study the spread of tau across the course of the disease as well as the cross-modal relationship between tau and other biomarkers. To better understand the pathobiology of Alzheimer's disease we measured levels of tau PET binding in individuals with dominantly inherited Alzheimer's disease using data from the Dominantly Inherited Alzheimer Network (DIAN). We examined cross-sectional measures of amyloid-β, tau, glucose metabolism, and grey matter degeneration in 15 cognitively normal mutation non-carriers, 20 asymptomatic carriers, and 15 symptomatic mutation carriers. Linear models examined the associatio...Continue Reading

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Mentioned in this Paper

Biological Markers
In Vivo
Magnetic Resonance Imaging
Uptake
Nerve Degeneration
Gray Matter
Cerebrospinal Fluid
Alzheimer's Disease
Amyloid
Cross-Sectional Studies

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