Tau phosphorylation and aggregation in Alzheimer's disease pathology

FEBS Letters
Jesús Avila

Abstract

In this article I shall review how tau phosphorylation and aggregation participates in Alzheimer's disease (AD) and other tauopathies. Tau, a microtubule associated protein, is the main component, in phosphorylated form, of the aberrant paired helical filaments found in AD. Tau is present in phosphorylated and aggregated form not only in AD, but in other pathologies (tauopathies). In this review, the phosphorylation of tau, its aggregation, and the possible relation between tau phosphorylation and aggregation is, briefly, described. Also, it is discussed the toxicity of modified tau. In addition, I propose a working model detailing the progression of tau pathologies.

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 29, 1989·Biochemical and Biophysical Research Communications·G V JohnsonL I Binder
Nov 1, 1989·Neurobiology of Aging·W BondareffD L Hauser
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Dec 1, 1986·The Journal of Cell Biology·D G Drubin, M W Kirschner
Dec 15, 1986·Biochemical and Biophysical Research Communications·E Montejo de GarciniJ Avila
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C M WischikA Klug
Jan 13, 1995·The Journal of Biological Chemistry·M Morishima-KawashimaY Ihara
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaK Imahori
Jun 18, 1998·Annals of Neurology·P PoorkajG D Schellenberg
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniB Ghetti
Aug 11, 1998·Nature Genetics·D L PriceD R Borchelt
Aug 6, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Goedert
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·M von BergenE Mandelkow
Aug 25, 2001·Annual Review of Neuroscience·V M LeeJ Q Trojanowski
Nov 13, 2003·The Journal of Biological Chemistry·Hideki ShimuraKenneth S Kosik
Nov 19, 2003·Journal of Alzheimer's Disease : JAD·Mar PérezJesús Avila
May 4, 2004·Annals of Neurology·Bart DermautPeter Paul De Deyn

❮ Previous
Next ❯

Citations

Aug 19, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anne EckertJürgen Götz
Jun 18, 2010·Amino Acids·S GrimmT Grune
Jun 29, 2007·Expert Reviews in Molecular Medicine·Jean-Christophe Rochet
Apr 30, 2009·The Journal of Biological Chemistry·Kensuke YotsumotoShin-Ichi Hisanaga
Jan 19, 2010·The Journal of Biological Chemistry·Jessica L Buescher, Christopher J Phiel
Oct 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tongjian CaiWenjing Luo
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Virginia M-Y LeeJohn Q Trojanowski
Oct 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rafael Giraldo
Sep 15, 2010·Psychiatry Research·Péter Z AlmosJános Kálmán
May 3, 2008·Chemical Reviews·Heather E Murrey, Linda C Hsieh-Wilson
Feb 28, 2013·The Journal of Biological Chemistry·Alex CroweKurt R Brunden
Apr 28, 2010·Expert Review of Neurotherapeutics·Siddhartha Mondragón-RodríguezMark A Smith
Apr 28, 2010·Expert Review of Neurotherapeutics·Jesús AvilaFélix Hernández
Nov 14, 2007·Expert Review of Neurotherapeutics·Jesús Avila, Félix Hernández
Aug 10, 2007·Expert Opinion on Investigational Drugs·Alistair J StewartIllana Gozes
Jan 7, 2015·Molecular Neurobiology·Yanuar Alan Sulistio, Klaus Heese
Dec 24, 2015·Journal of Medicinal Chemistry·Rita M C Di MartinoFederica Belluti
Aug 21, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Filippo MulinacciTudor Arvinte
Jul 6, 2010·Brain Research Bulletin·Chang-Jun LinZhao-Feng Jiang
Jul 9, 2014·Journal of Neuropathology and Experimental Neurology·Carol A ColtonMichael P Vitek
Sep 21, 2013·Scientific Reports·Katarina JovanovicStefan F T Weiss
Jan 9, 2015·Scientific Reports·Ilya ChumakovDaniel Cohen
Apr 1, 2016·Journal of Neuropathology and Experimental Neurology·Vidya S KrishnanMiranda D Grounds
Mar 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Houssem BoulebdJosé Marco-Contelles
Oct 7, 2015·Frontiers in Neuroscience·Gunjan JoshiYanzhuang Wang
Feb 18, 2015·Journal of Molecular Neuroscience : MN·Qing-Guo RenZhi-Jun Zhang
Jun 30, 2012·Ageing Research Reviews·Ludovic MartinFaraj Terro
Mar 10, 2007·Neurobiology of Aging·Shannon L BianchiMaryellen F Eckenhoff
Dec 18, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kurt R BrundenVirginia M-Y Lee
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
Apr 15, 2017·Journal of Pharmacological Sciences·Eun-Jeong YangHye-Sun Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

FEBS Letters
Alberto Gómez-RamosJesús Avila
Proceedings of the National Academy of Sciences of the United States of America
I Grundke-IqbalLester I Binder
Biochimica Et Biophysica Acta
K IqbalI Grundke-Iqbal
Proceedings of the National Academy of Sciences of the United States of America
C L MastersK Beyreuther
© 2021 Meta ULC. All rights reserved