Tau Protein in Oral Mucosa and Cognitive State: A Cross-sectional Study

Frontiers in Neurology
Luis Fernando ArredondoMaria E Jimenez-Capdeville

Abstract

Neurodegenerative diseases are characterized by the presence of abnormal aggregates of proteins in brain tissue. Among them, the presence of aggregates of phosphorylated Tau protein (p-Tau) is the hallmark of Alzheimer's disease (AD) and other major neurodegenerative disorders such as corticobasal degeneration and frontotemporal dementia among others. Although Tau protein has previously been assumed to be exclusive to the central nervous system, it is also found in peripheral tissues. The purpose of this study was to determine whether there is a differential Tau expression in oral mucosa cells according to cognitive impairment. Eighty-one subjects were enrolled in the study and classified per Mini-Mental State Examination test score into control, mild cognitive impairment (MCI), and severe cognitive impairment (SCI) groups. Immunocytochemistry and immunofluorescence revealed the presence of Tau and four p-Tau forms in the cytoplasm and nucleus of oral mucosa cells. More positivity was present in subjects with cognitive impairment than in control subjects, both in the nucleus and cytoplasm, in a speckle pattern. The mRNA expression of Tau by quantitative real-time polymerase chain reaction was higher in SCI as compared with the ...Continue Reading

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Citations

Feb 19, 2021·Neurodegenerative Disease Management·Felix Menne, Carola G Schipke

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Methods Mentioned

BETA
ELISA
imaging techniques
flow cytometry
fluorescence microscopy
confocal microscopy
PCR
light microscopy

Software Mentioned

GraphPad Prism
Image Pro Plus
GraphPad

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