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Tau protein liquid-liquid phase separation can initiate tau aggregation

The EMBO Journal

Feb 24, 2018

Susanne WegmannBradley T Hyman

Abstract

The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separ...read more

Mentioned in this Paper

TARDBP gene
Familial Alzheimer Disease (FAD)
Heterogeneous Nuclear Ribonucleoprotein A1
HEK293 Cells
Alkalescens-Dispar Group
TDP-43 protein, human
Neurofibrillary Degeneration (Morphologic Abnormality)
Proteins, Recombinant DNA
Biophysical Processes
Neurons
44
2
451
Paper Details
References
  • References97
  • Citations28
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  • References97
  • Citations28
123

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Tau protein liquid-liquid phase separation can initiate tau aggregation

The EMBO Journal

Feb 24, 2018

Susanne WegmannBradley T Hyman

PMID: 29472250

DOI: 10.15252/embj.201798049

Abstract

The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separ...read more

Mentioned in this Paper

TARDBP gene
Familial Alzheimer Disease (FAD)
Heterogeneous Nuclear Ribonucleoprotein A1
HEK293 Cells
Alkalescens-Dispar Group
TDP-43 protein, human
Neurofibrillary Degeneration (Morphologic Abnormality)
Proteins, Recombinant DNA
Biophysical Processes
Neurons
44
2
451

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Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

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Paper Details
References
  • References97
  • Citations28
12345...
  • References97
  • Citations28
123

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