Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells

Journal of Neurochemistry
C L SayasJesús Ávila

Abstract

The axonal microtubule-associated protein tau is a well-known regulator of microtubule stability in neurons. However, the putative interplay between tau and End-binding proteins 1 and 3 (EB1/3), the core microtubule plus-end tracking proteins, has not been elucidated yet. Here, we show that a cross-talk between tau and EB1/3 exists in developing neuronal cells. Tau and EBs partially colocalize at extending neurites of N1E-115 neuroblastoma cells and axons of primary hippocampal neurons, as shown by confocal immunofluorescence analyses. Tau down-regulation leads to a reduction of EB1/3 comet length, as observed in shRNA-stably depleted neuroblastoma cells and TAU-/- neurons. EB1/3 localization depends on the expression levels and localization of tau protein. Over-expression of tau at high levels induces EBs relocalization to microtubule bundles at extending neurites of N1E-115 cells. In differentiating primary neurons, tau is required for the proper accumulation of EBs at stretches of microtubule bundles at the medial and distal regions of the axon. Tau interacts with EB proteins, as shown by immunoprecipitation in different non-neuronal and neuronal cells and in whole brain lysates. A tau/EB1 direct interaction was corroborated...Continue Reading

References

May 13, 1977·Brain Research·G A Banker, W M Cowan
Aug 1, 1991·The Journal of Cell Biology·J KnopsL McConlogue
May 1, 1990·Brain Research. Brain Research Reviews·R P Tucker
Dec 1, 1986·The Journal of Cell Biology·D G Drubin, M W Kirschner
Dec 15, 1982·European Journal of Biochemistry·J FranconJ Nunez
Jan 1, 1994·International Review of Cytology·T A Schoenfeld, R A Obar
Feb 24, 2000·Neurochemical Research·G PagliniA Caceres
Apr 10, 2002·Molecular and Cellular Biology·Frédéric M CoquelleOrly Reiner
Nov 26, 2002·The Journal of Cell Biology·Yulia A KomarovaGary G Borisy
Dec 31, 2002·The EMBO Journal·Santwana KarLinda A Amos
Jun 14, 2003·The Journal of Biological Chemistry·Victoria MakridesStuart C Feinstein
Mar 27, 2004·Physiological Reviews·Jesus AvilaFelix Hernandez
Mar 25, 2005·Journal of Neuroscience Research·Eva M Jiménez-MateosJesús Avila
Apr 29, 2006·Traffic·Gideon Lansbergen, Anna Akhmanova
Jun 29, 2007·Neurochemistry International·Junko FujioShinobu C Fujita
Dec 7, 2007·Nature·Peter BielingThomas Surrey
Apr 15, 2008·Molecular and Cellular Neurosciences·Madelaine M RosenbergMichele H Jacob
Aug 20, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F LéveilléA Buisson
Jan 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ram DixitErika L F Holzbaur
Jan 17, 2009·Neuron·Jacek JaworskiCasper C Hoogenraad
Mar 4, 2009·The Journal of Cell Biology·Yulia KomarovaAnna Akhmanova
Apr 18, 2009·Nature Reviews. Molecular Cell Biology·Laura Anne Lowery, David Van Vactor
Apr 21, 2009·Nature Reviews. Neuroscience·Cecilia Conde, Alfredo Cáceres
Dec 17, 2009·Neurobiology of Disease·Elena Gómez de BarredaJesús Avila
May 18, 2010·Current Biology : CB·Tatiana StepanovaNiels Galjart
Jul 14, 2010·Current Biology : CB·Niels Galjart
Aug 4, 2010·Current Alzheimer Research·K IqbalI Grundke-Iqbal
May 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christophe LeterrierBénédicte Dargent
Jun 3, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lukas C KapiteinCasper C Hoogenraad
Sep 23, 2011·Genes & Development·Eun-Mi HurFeng-Quan Zhou
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juliana Alves-SilvaAndreas Prokop
Oct 23, 2012·Molecular Biology of the Cell·Aranda R Duan, Holly V Goodson

❮ Previous
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Citations

Mar 13, 2016·Cellular and Molecular Life Sciences : CMLS·Dieudonnée van de WilligeAnna Akhmanova
Oct 7, 2015·Frontiers in Cellular Neuroscience·Jyoti DubeySandhya P Koushika
Sep 1, 2015·Journal of Molecular Neuroscience : MN·Anna MalishkevichIllana Gozes
Apr 23, 2016·Biomolecules·Miguel MedinaJesús Avila
Oct 26, 2016·Brain Research Bulletin·André VoelzmannAndreas Prokop
Sep 30, 2016·Frontiers in Cellular Neuroscience·Jayden A ClarkTracey C Dickson
Jul 29, 2016·Molecular Biology of the Cell·Sacnicte Ramirez-RiosIsabelle Arnal
Dec 1, 2017·Acta Neuropathologica Communications·Ioannis SotiropoulosLuc Buee
Oct 6, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amrita RamkumarKassandra M Ori-McKenney
May 21, 2016·The EMBO Journal·Noemí Pallas-BazarraMaría Llorens-Martín
Nov 24, 2016·Frontiers in Aging Neuroscience·Jesus AvilaFelix Hernández
Mar 15, 2018·The Journal of Cell Biology·Coralie FassierJamilé Hazan
Feb 17, 2017·Cellular and Molecular Life Sciences : CMLS·Anne NehligClara Nahmias
Mar 3, 2020·Frontiers in Neuroscience·Sébastien FeuilletteMagalie Lecourtois
Jun 27, 2020·Journal of Molecular Neuroscience : MN·Yanina Ivashko-Pachima, Illana Gozes
Nov 19, 2015·Frontiers in Aging Neuroscience·Illana Gozes, Yanina Ivashko-Pachima
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Félix HernándezJesús Avila
Jul 12, 2017·Frontiers in Cellular Neuroscience·Peter VerstraelenWinnok H De Vos
Oct 19, 2017·Journal of Alzheimer's Disease : JAD·Jesús Avila
Oct 22, 2019·Frontiers in Cellular Neuroscience·Yanina Ivashko-Pachima, Illana Gozes
Oct 21, 2020·Cellular and Molecular Life Sciences : CMLS·Yifan ZengYongqi Huang
May 4, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Pradeepkiran Jangampalli Adi, P Hemachandra Reddy
Jun 5, 2021·Oncotarget·Shweta Kishor Sonawane, Subashchandrabose Chinnathambi
Feb 24, 2021·Plant Physiology·Laining ZhangAndrei Smertenko

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