Tau13 Antibody Preferentially Immunoprecipitates High Molecular Weight Tau Proteins

Journal of Alzheimer's Disease : JAD
Andrew Umstead, Irving E Vega

Abstract

The accumulation of tau protein aggregates is a pathological hallmark in Alzheimer's disease (AD) and other neurodegenerative diseases. However, the identity of the toxic tau conformation that propagates and induces neurodegeneration is still unknown. Anti-tau antibodies are a common tool used to differentiate between normal and pathological-associated tau forms or as passive immunotherapy in the quest to interfere with tau-mediated neurodegeneration. Here, we show that Tau13, a tau N-terminal antibody, preferentially enriches high molecular weight tau species produced in a tauopathy mouse model and AD. The data suggest that Tau13 has higher affinity to specific tau conformation presence in higher molecular weight tau species.

References

Aug 25, 2001·Annual Review of Neuroscience·V M LeeJ Q Trojanowski
Dec 24, 2004·Biochimica Et Biophysica Acta·Khalid IqbalInge Grundke-Iqbal
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Alix de CalignonBradley T Hyman
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas M KanaanLester I Binder
Mar 1, 2012·Neuron·Alix de CalignonBradley T Hyman
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michiyo IbaVirginia M-Y Lee
Sep 4, 2013·The Journal of Clinical Investigation·Laura J BlairChad A Dickey
Dec 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kishore V KuchibhotlaBradley T Hyman
Apr 15, 2017·The American Journal of Pathology·Chloe K NobuharaShuko Takeda
Apr 18, 2017·The American Journal of Pathology·Benjamin Combs, Nicholas M Kanaan
Dec 24, 2017·Nature Neuroscience·Daniel J ApiccoBenjamin Wolozin
Jan 5, 2018·Cellular and Molecular Neurobiology·Fong Ping ChongSoi Moi Chye
Sep 19, 2018·Journal of Alzheimer's Disease : JAD·Alexander J EhrenbergLea T Grinberg

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Methods Mentioned

BETA
transgenic
immunoprecipitation

Software Mentioned

Image Studio

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