Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation

Journal of Neuroinflammation
Boris MravecR Kvetnansky

Abstract

Brain norepinephrine (NE) plays an important role in the modulation of stress response and neuroinflammation. Recent studies indicate that in Alzheimer's disease (AD), the tau neuropathology begins in the locus coeruleus (LC) which is the main source of brain NE. Therefore, we investigated the changes in brain NE system and also the immune status under basal and stress conditions in transgenic rats over-expressing the human truncated tau protein. Brainstem catecholaminergic cell groups (LC, A1, and A2) and forebrain subcortical (nucleus basalis of Meynert), hippocampal (cornu ammonis, dentate gyrus), and neocortical areas (frontal and temporal association cortices) were analyzed for NE and interleukin 6 (IL-6) mRNA levels in unstressed rats and also in rats exposed to single or repeated immobilization. Moreover, gene expression of NE-biosynthetic enzyme, tyrosine hydroxylase (TH), and several pro- and anti-inflammatory mediators were determined in the LC. It was found that tauopathy reduced basal NE levels in forebrain areas, while the gene expression of IL-6 was increased in all selected areas at the same time. The differences between wild-type and transgenic rats in brain NE and IL-6 mRNA levels were observed in stressed anim...Continue Reading

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Citations

Aug 4, 2016·Stress : the International Journal on the Biology of Stress·Richard KvetnanskyBoris Mravec
Oct 21, 2017·Brain : a Journal of Neurology·Jacki M RorabaughDavid Weinshenker
Oct 19, 2017·Neural Plasticity·Termpanit ChalermpalanupapJacki M Rorabaugh
Nov 7, 2019·Journal of Neuroinflammation·Song CaoHongxin Dong
Apr 14, 2017·Cellular and Molecular Neurobiology·Petr NovakPeter Filipcik
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Petr NovakMichal Novak
Dec 23, 2019·European Journal of Medicinal Chemistry·Cun-Jian ShiXiao-Bing Wang
Nov 20, 2020·International Journal of Molecular Sciences·Filippo Sean GiorgiFrancesco Fornai
Feb 25, 2018·Trends in Neurosciences·David Weinshenker

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Methods Mentioned

BETA
transgenic
dissection
protein assay
PCR
electrophoresis
pharmacotherapy

Software Mentioned

Image Studio
Excel
SigmaPlot

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