Abstract
Taurine plays a role in neuronal development. In this study, we examined whether postnatal taurine administration influences the long-term consequences induced by mild neonatal stressors (10 min maternal deprivation plus sham injection, applied daily to neonatal mice up to 21 days). At 30 days of age stressed mice showed higher pain threshold both in the tail-flick--which measures mostly the spinal mechanisms of pain--and in the hot-plate test--which reflects mainly the supraspinal mechanisms of pain. The latter effect was prevented completely by neonatal taurine administration, while the tail-flick test was not affected, thus suggesting that spinal pain is not sensitive to taurine treatment. At 140 days of age, mice which were stressed during the neonatal period showed consistent decrease in immobility time in forced swimming test, and taurine did not influence this parameter. At the same age, the fear/anxiety axis, measured with elevated plus maze test, did not show any consistent changes. Electrophysiological experiments in brain slices obtained from adult mice showed that input-output curves in hippocampal CA1 were increased by taurine administration in lactation. Hence, neonatal administration of taurine might permanently ...Continue Reading
References
Jul 1, 1978·Developmental Psychobiology·S G Wiener, S Levine
Jan 1, 1989·Biology of the Neonate·K Shiota, T Kayamura
Aug 1, 1970·Experimental Neurology·E Fifkova, A Van Harreveld
Feb 1, 1984·Neuropharmacology·T S JensenD F Smith
Oct 15, 1982·Biochemical Pharmacology·F FranconiA Giotti
Jun 1, 1995·Current Opinion in Neurobiology·A U Larkman, J J Jack
Dec 1, 1994·British Journal of Pharmacology·S PierettiA Loizzo
Jun 1, 1993·Journal of Pharmacological and Toxicological Methods·S L Handley, J W McBlane
Mar 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·D Servant, P J Parquet
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Oct 1, 1996·Journal of Biosocial Science·R Morley
Apr 1, 1997·Behavioural Brain Research·A RamosF Chaouloff
Feb 12, 1998·Neuron·A C FlintA R Kriegstein
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·P Legendre
Aug 14, 2001·Psychoneuroendocrinology·M L Boccia, C A Pedersen
Oct 31, 2001·Public Health Nutrition·K M Godfrey, D J Barker
Oct 10, 2002·Brain Research Bulletin·E R G SanabriaM J S Fernandes
Nov 5, 2002·Trends in Pharmacological Sciences·Bodo LaubeHeinrich Betz
Jun 12, 2003·Hormones and Behavior·Russell D RomeoWayne G Brake
Citations
Aug 19, 2007·Proceedings. Biological Sciences·Kathryn E ArnoldAileen Adam
Oct 10, 2012·The Journal of Endocrinology·Alberto LoizzoStefano Loizzo
Oct 17, 2012·Amino Acids·Sanya Roysommuti, J Michael Wyss
Sep 22, 2007·Life Sciences·Rie SugeMasahiko Nomura
May 12, 2007·Early Human Development·Alberto LoizzoFlavia Franconi
Jan 31, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Flavia FranconiGiuseppe Seghieri
Nov 23, 2017·The Journal of Pharmacology and Experimental Therapeutics·Alberto LoizzoStefano Loizzo