Taurine administration during lactation modifies hippocampal CA1 neurotransmission and behavioural programming in adult male mice

Brain Research Bulletin
Flavia FranconiAlberto Loizzo

Abstract

Taurine plays a role in neuronal development. In this study, we examined whether postnatal taurine administration influences the long-term consequences induced by mild neonatal stressors (10 min maternal deprivation plus sham injection, applied daily to neonatal mice up to 21 days). At 30 days of age stressed mice showed higher pain threshold both in the tail-flick--which measures mostly the spinal mechanisms of pain--and in the hot-plate test--which reflects mainly the supraspinal mechanisms of pain. The latter effect was prevented completely by neonatal taurine administration, while the tail-flick test was not affected, thus suggesting that spinal pain is not sensitive to taurine treatment. At 140 days of age, mice which were stressed during the neonatal period showed consistent decrease in immobility time in forced swimming test, and taurine did not influence this parameter. At the same age, the fear/anxiety axis, measured with elevated plus maze test, did not show any consistent changes. Electrophysiological experiments in brain slices obtained from adult mice showed that input-output curves in hippocampal CA1 were increased by taurine administration in lactation. Hence, neonatal administration of taurine might permanently ...Continue Reading

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Citations

Aug 19, 2007·Proceedings. Biological Sciences·Kathryn E ArnoldAileen Adam
Oct 10, 2012·The Journal of Endocrinology·Alberto LoizzoStefano Loizzo
Oct 17, 2012·Amino Acids·Sanya Roysommuti, J Michael Wyss
Sep 22, 2007·Life Sciences·Rie SugeMasahiko Nomura
May 12, 2007·Early Human Development·Alberto LoizzoFlavia Franconi
Jan 31, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Flavia FranconiGiuseppe Seghieri
Nov 23, 2017·The Journal of Pharmacology and Experimental Therapeutics·Alberto LoizzoStefano Loizzo

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