PMID: 9428497Jan 15, 1998Paper

Taurine attenuates recombinant interleukin-2-activated, lymphocyte-mediated endothelial cell injury

Cancer
N M FinneganD J Bouchier-Hayes

Abstract

Recombinant interleukin-2 (rIL-2) immunotherapy is limited by microvascular endothelial cell (EC)-targeted injury. The interaction between rIL-2-activated lymphoid cells and EC is a possible mechanism of this systemic toxicity. Taurine, a beta-amino acid, is known to have several physiologic actions, including the modulation of calcium homeostasis. The aims of this study were to analyze the effects of taurine on rIL-2-activated, lymphocyte-mediated EC and tumor cell cytotoxicity and to investigate the mechanisms of its action. IL-2-activated cytotoxicity, mediated by peripheral blood mononuclear cells, against susceptible tumor cell lines and against EC (fresh EC and an EC cell line) in the presence of taurine was assessed. The effects of taurine on lymphocyte [Ca2+]i were assessed by flow cytometry, and the effects of taurine on granzyme activity were assessed by spectrophotometry. The authors' findings indicated that the addition of taurine significantly reduced rIL-2-activated EC cytotoxicity mediated by natural killer cells, without reducing antitumor response. Taurine was also shown to reduce significantly EC lysis mediated by lymphokine-activated killer (LAK) cells, while also significantly increasing tumor cytotoxicity. ...Continue Reading

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·M A BanksV Castranova
Jan 1, 1992·Physiological Reviews·R J Huxtable
Nov 1, 1991·Archives of Otolaryngology--head & Neck Surgery·B B BurkeyG T Wolf
Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J R BenderE Engleman
Jul 1, 1989·The American Journal of the Medical Sciences·D E BechardF L Glauser
Sep 1, 1987·European Journal of Immunology·A M MiltenburgL C Paul
Mar 1, 1995·The Journal of Cell Biology·S PfauJ R Bender
Sep 1, 1993·Metabolism: Clinical and Experimental·M IkebuchiY Shigeta

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Citations

Apr 14, 2009·International Immunopharmacology·Georgia Schuller-LevisEunkyue Park
May 31, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Mehmet Ali ErgunNecat Imirzalioglu
Feb 16, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eunkyue ParkGeorgia Schuller-Levis
Apr 18, 2006·Irish Journal of Medical Science·G C O'BrienH P Redmond
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·T MekhailR Bukowski

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