Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy

Chemical Communications : Chem Comm
Enming DuYe Zhang

Abstract

The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species. These characteristic features make the taurine-modified Ru-complex a potentially effective photosensitizer for PDT of target cancer cells, with outstanding efficacy in cancerous brain cells.

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Citations

Apr 13, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Yun MaWai-Yeung Wong
Jan 18, 2019·International Journal of Molecular Sciences·Dik-Lung MaChung-Hang Leung
Aug 4, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Utpal DasPriyankar Paira
May 29, 2019·ACS Applied Materials & Interfaces·Peng GaoBo Tang
Oct 10, 2018·Chemical Reviews·Xiaohui WangZijian Guo
Nov 4, 2021·The Journal of Pharmacology and Experimental Therapeutics·Fátima Virgínia Gama JustiReinaldo Barreto Oriá

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