Taurine prevents mitochondrial membrane permeabilization and swelling upon interaction with manganese: Implication in the treatment of cirrhosis-associated central nervous system complications

Journal of Biochemical and Molecular Toxicology
Nahid AhmadiReza Heidari

Abstract

Brain tissue manganese (Mn) accumulation is a cirrhosis-associated complication. Cellular mitochondria are among the potential targets for Mn-induced cytotoxicity. Taurine is one of the most abundant amino acids with high concentrations in human brain tissue. Several pharmacological properties including regulation of mitochondrial function are attributed to taurine. The current investigation was designed to evaluate the effect of taurine on Mn-induced mitochondrial impairment in isolated mice brain mitochondria. The brain mitochondria were exposed to increasing concentrations of Mn (0.1-10 mM). Taurine (0.1, 1, and 10 mM) was added as the protective agent. The severe collapse of mitochondrial membrane potential, decreased mitochondrial dehydrogenases activity, mitochondrial swelling, and depleted mitochondrial adenosine triphosphate (ATP) were evident in Mn-exposed mitochondria. It was found that taurine administration preserved mitochondrial ATP, prevented mitochondrial depolarization and swelling, and increased mitochondrial dehydrogenases activity. These data suggest mitochondrial protection as an underlying mechanism for the protective effects of taurine against Mn toxicity.

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Citations

Oct 26, 2018·Biological Trace Element Research·Mohammad Mehdi OmmatiHossein Niknahad
Jun 9, 2020·Stress : the International Journal on the Biology of Stress·Mohammad Mehdi OmmatiReza Heidari
Sep 24, 2020·International Journal of Molecular Sciences·Hiroaki HirataNorio Kawahara
Sep 25, 2019·International Journal of Environmental Research and Public Health·Airton Cunha MartinsMichael Aschner
Jun 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahedeh SamadiMohammad Abdollahi
Aug 8, 2021·International Journal of Molecular Sciences·Beata TarnackaMaria Maślińska

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