Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish

Molecular Neurobiology
Barbara D FontanaDenis B Rosemberg

Abstract

Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures, which culminate in various neurobehavioral and neurochemical changes. Taurine (TAU) is an amino sulfonic acid which acts an endogenous inhibitory neuromodulator. Moreover, TAU displays intrinsic antioxidant activity, contributing to its beneficial actions in the CNS. Here, we evaluated whether TAU pretreatment protects from pentylenetetrazole (PTZ)-induced behavioral alterations and oxidative stress-related parameters in zebrafish brain tissue. Fish were pretreated with 42, 150, and 400 mg/L TAU (40 min) and further exposed to 10 mM PTZ (20 min) to analyze the seizure-like behaviors. As a positive control, another group was previously treated with 75 μM diazepam (DZP). Afterwards, biochemical experiments were performed. All TAU concentrations tested decreased seizure intensity in the first 150 s. Importantly, 150 mg/L TAU attenuated seizure-like behavioral scores, decreased seizure intensity, reduced the frequency of clonic-like seizures (score 4), and increased the latency to score 4. TAU (150 mg/L) also prevented oxidative stress in PTZ-challenged fish by decreasing lipid peroxidation and protein carbonylation and preventing changes on ...Continue Reading

References

Mar 1, 1977·Epilepsia·N M van GelderH H Jasper
Feb 1, 1978·Neurochemical Research·D I Carruthers-Jones, N M van Gelder
Jan 1, 1992·Advances in Experimental Medicine and Biology·J Y WuW H Tsai
Jan 1, 1992·Physiological Reviews·R J Huxtable
Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Oct 1, 1985·Experimental Neurology·A Vezzani, R Schwarcz
Aug 1, 1973·Canadian Journal of Physiology and Pharmacology·K IzumiA Barbeau
Jan 1, 1984·Methods in Enzymology·H Aebi
Jul 8, 2000·Epilepsia·R S Greenwood
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·R GerlaiA Rosenthal
Jun 8, 2001·Trends in Pharmacological Sciences·E J Calabrese, L A Baldwin
Jan 15, 2002·Advances in Experimental Medicine and Biology·J Y WuC C Hsu
Dec 10, 2002·Cellular and Molecular Neurobiology·Ivaldo J L OliveiraCarla I Tasca
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Mar 11, 2005·Brain Research·Heng WuJang-Yen Wu
Sep 9, 2005·Epilepsia·Robert S FisherUNKNOWN Epilepsy Foundation of America Working Group
Sep 27, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·E MarianiP Mecocci
Aug 31, 2007·Annals of Nutrition & Metabolism·Cheng Gao Zhang, Sung-Jin Kim
Oct 7, 2008·Archives of Biochemistry and Biophysics·Lúcia Maria Vieira de AlmeidaCarmem Gottfried
Nov 26, 2008·Journal of Neuroscience Research·F JunyentC Auladell
Aug 12, 2009·Nature Reviews. Neurology·Rainer SurgesJosemir W Sander
Nov 7, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Ana Flávia FurianCarlos Fernando Mello
Jun 1, 2010·Behavioural Brain Research·Caio MaximinoAmauri Gouveia
Jun 22, 2010·Behavioural Brain Research·Leah GrossmanAllan V Kalueff
Feb 5, 2011·Seizure : the Journal of the British Epilepsy Association·Wolfgang Löscher
Feb 8, 2011·Journal of Neural Transmission·Ewa PoleszakPiotr Wlaź
Mar 8, 2011·The European Journal of Neuroscience·Juan M AlfaroJavier S Burgos
Mar 17, 2011·PloS One·Jonathan CachatAllan V Kalueff
Jun 22, 2011·Journal of Neuroscience Methods·Ricardo PinedaCharles W Hall
Jul 23, 2011·The Journal of Biological Chemistry·Victor VitvitskyRuma Banerjee
Oct 25, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jingyun WangYachen Li
May 29, 2012·Neuropharmacology·Denis B RosembergDiogo O Souza

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Citations

Jan 8, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Baoyue ZhangMeng Jin
Mar 29, 2019·Biomolecules & Therapeutics·Jung Hwa Jung, Sung-Jin Kim
Feb 12, 2019·Hormones and Behavior·Nathana J MezzomoLeonardo J G Barcellos

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