PMID: 8591791Nov 1, 1995Paper

Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia

Experimental Lung Research
G B Schuller-LevisD L Laskin

Abstract

Ozone is a potent respiratory irritant known to induce lung injury in humans and experimental animals. The present studies determined if ozone-induced lung inflammation was modified by pretreatment of animals with taurine, a detoxifying antioxidant. Rats were pretreated for 10 days with 5% taurine in their drinking water (controls received water only) prior to exposure to 2 ppm ozone for 3 h. At 2, 6, 12, 24, 48, and 72 h after ozone exposure, rats were anesthetized and the lungs were perfusion-fixed for histopathologic evaluation. An additional group of rats was used to examine bronchoalveolar lavage cell counts and hydroxyproline levels. A count of bronchoalveolar lavage cells 48 h after ozone exposure showed significantly fewer total inflammatory cells and fewer polymorphonuclear leukocytes accompanied by a reduction in hydroxyproline in the lavage fluid of ozone-exposed rats pretreated with taurine compared to rats that did not receive taurine. Light microscopy revealed an inflammatory cell infiltrate in the lungs of rats exposed to ozone. This was followed by focal hyperplasia in the terminal and respiratory bronchioles. Rats pretreated with taurine and then exposed to ozone showed none of these alterations. In addition, a...Continue Reading

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Citations

Nov 22, 2001·European Journal of Pharmacology·J CortijoE J Morcillo
Nov 22, 2001·Immunology Letters·Yong Liu, Michael R Quinn
Apr 4, 1998·American Journal of Respiratory Cell and Molecular Biology·G GurujeyalakshmiS N Giri
Apr 14, 2009·International Immunopharmacology·Georgia Schuller-LevisEunkyue Park
Feb 16, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eunkyue ParkGeorgia Schuller-Levis
Oct 30, 2016·Chemical Research in Toxicology·Dinesh K BarupalOliver Fiehn
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·T W Stief, J Fareed
Oct 15, 2019·Frontiers in Immunology·Milena SokolowskaDieudonnée Togbe
Dec 21, 2006·Molecular and Cellular Biochemistry·Joemerson Osório RosadoDiego Bonatto
May 9, 2002·Biochimica Et Biophysica Acta·Eunkyue ParkGeorgia Schuller-Levis

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