Taurine provides a time-dependent amelioration of the brain damage induced by γ-irradiation in rats

Journal of Hazardous Materials
Engy F El-MaraghiWael M El-Sayed

Abstract

Exposure to ionizing radiation (IR) is inevitable since over 80% of total average exposure comes from natural sources. Brain is vulnerable to the deleterious effects of IR. Therefore, scientists paid attention in identifying novel compounds to protect against radiation-induced brain injury. Adult male albino rats weighing 120-150 g were divided into five groups, 18 rats each. Group 1 served as control, group 2 received an oral daily dose of taurine (500 mg/kg) for 2 weeks. Group 3 was exposed to a whole body single dose of γ-irradiation (6 Gy). Groups 4 and 5 received taurine before and after γ-irradiation, respectively. Six rats from each group were sacrificed after 1, 2 or 3 weeks. Throughout the 3 weeks studied, there were significant increases in MDA, NO, TNF-α levels, and Cytochrome-c and activities of Caspases -9 and -3 and significant decreases in GSH, SOD, CAT and GPx in the irradiated group when compared with the relevant control. Cerebral cortex of irradiated rats showed vacuolization and nuclear pyknosis in the neuronal cells and focal gliosis. Taurine administration pre- or post-irradiation significantly ameliorated all these previous effects. Taurine had antioxidant, anti-inflammatory, and anti-apoptotic effects an...Continue Reading

Citations

Sep 30, 2020·International Journal of Radiation Biology·Engy F El-MaraghiWael M El-Sayed
Oct 18, 2019·Frontiers in Neuroscience·Elian da Silva FranciscoRubem Carlos Araújo Guedes
Nov 9, 2019·Dose-response : a Publication of International Hormesis Society·Yiying GaoJianping Cao
Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Shashank ShrishrimalRebecca E Oberley-Deegan
Jun 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Won Jin LeeHan Geuk Seo
May 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying ZhengBaiping Ma

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