Taurine Reduces tPA (Tissue-Type Plasminogen Activator)-Induced Hemorrhage and Microvascular Thrombosis After Embolic Stroke in Rat

Stroke; a Journal of Cerebral Circulation
Rong JinGuohong Li

Abstract

Taurine (2-aminoethansulfolic amino acid) exerts neuroprotective actions in experimental stroke. Here, we investigated the effect of taurine in combination with delayed tPA (tissue-type plasminogen activator) on embolic stroke. Rats subjected to embolic middle cerebral artery occlusion were treated with taurine (50 mg/kg) at 4 hours in combination with tPA (10 mg/kg) at 6 hours. Control groups consisted of ischemic rats treated with either taurine (50 mg/kg) or saline at 4 hours or tPA (10 mg/kg) alone at 2 or 6 hours after middle cerebral artery occlusion. We found that combination treatment with taurine and tPA robustly reduced infarct volume and neurological deficits 3 days after stroke, whereas treatment with taurine alone had a less-significant protective effect. tPA alone at 6 hours had no effects on infarct volume but instead induced intracerebral hemorrhage. The combination treatment with taurine prevented tPA-associated hemorrhage and reduced intravascular deposition of fibrin/fibrinogen and platelets in downstream microvessels and hence improved microvascular patency. These protective effects are associated with profound inhibition of CD147 (cluster of differentiation 147)-dependent MMP-9 (matrix metalloproteinase-9) ...Continue Reading

References

Jan 1, 1992·Physiological Reviews·R J Huxtable
Dec 1, 1988·Experimental Neurology·T D Hernandez, T Schallert
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M AsahiE H Lo
Jan 15, 2002·Advances in Experimental Medicine and Biology·Y S Kang
Nov 19, 2002·Amino Acids·J D Militante, J B Lombardini
Jan 17, 2004·Stroke; a Journal of Cerebral Circulation·Andrei V AlexandrovJames C Grotta
Oct 2, 2004·Stroke; a Journal of Cerebral Circulation·Xiaoying WangEng H Lo
Mar 28, 2006·Nature Medicine·Bing-Qiao ZhaoEng H Lo
Jun 17, 2008·Stroke; a Journal of Cerebral Circulation·Andreas KastrupChristoph Terborg
Oct 18, 2008·Stroke; a Journal of Cerebral Circulation·Yoshihiro MurataEng H Lo
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Marc FisherUNKNOWN STAIR Group
May 30, 2009·Stroke; a Journal of Cerebral Circulation·Deidre A De SilvaUNKNOWN Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) Investigators
Jul 30, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Li ZhangZheng Gang Zhang
Oct 20, 2010·Annals of the New York Academy of Sciences·Olivier A Harari, James K Liao
May 19, 2012·Trends in Pharmacological Sciences·Li ZhangMichael Chopp
Oct 25, 2012·Journal of Neurochemistry·Yasemin Gursoy-OzdemirTurgay Dalkara
Jan 1, 2014·Current Medicinal Chemistry·X ZhuG Li
Jan 1, 2013·Brain Sciences·Janet MenzieJang-Yen Wu
Oct 8, 2015·Stroke; a Journal of Cerebral Circulation·Jean-Philippe DesillesMikael Mazighi
Dec 24, 2015·Stroke; a Journal of Cerebral Circulation·Bart M DemaerschalkUNKNOWN American Heart Association Stroke Council and Council on Epidemiology and Prevention
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jun 6, 2017·Therapeutic Advances in Cardiovascular Disease·Mehdi AhmadianStephen R Stannard
Aug 30, 2017·Advances in Experimental Medicine and Biology·Howard PrenticeJang-Yen Wu

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Citations

Nov 4, 2020·Translational Stroke Research·Yinghua JiangXiaoying Wang
Feb 19, 2021·Journal of Stroke·Dmitri NikitinDong-Eog Kim
Aug 21, 2021·Journal of Neurointerventional Surgery·Claire RozesUNKNOWN ETIS Registry Investigators

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