Tautomeric-Dependent Lactam Cycloaddition with Nitrile Oxide: Facile Synthesis of 1,2,4-Oxadiazole[4,5-a ]indolone Derivatives

ACS Omega
Kun-Ming JiangJun Lin

Abstract

A concise, metal-free, and gram-scale strategy to convert indoline-2,3-diones to 1,2,4-oxadiazole[4,5-a]indolones through an improved [3 + 2] cycloaddition of α-ketone-lactam with nitrile oxides has been developed. The lactim form of the resonance structure of isatin in protic solvents is the key active dipolarophile that shows chemo- and regioselectivity under experimental and theoretical conditions. This strategy conveniently enabled the assembly of several 1,2,4-oxadiazole[4,5-a]indolines with a broad range of functional groups. Compounds 3a and 4b exhibit cytotoxicity in the NCI/ADR-RES, SKOV3, and OVCAR8 cell lines.

References

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Citations

Aug 23, 2019·The Journal of Organic Chemistry·Changwei Chen, Sunliang Cui

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Methods Mentioned

BETA
nuclear magnetic resonance
Assay
column chromatography
NMR

Software Mentioned

GaussView

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