Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Kojiro ShimozumaFrederick H Hausheer

Abstract

To elucidate whether adjuvant taxane monotherapy is a feasible and tolerable for postoperative breast cancer patients, we evaluated the severity of chemotherapy-induced peripheral neuropathy (CIPN) and the relative tolerability of regimens by health-related quality of life (HRQOL) assessment in node-positive breast cancer patients treated with taxane-containing regimens. We evaluated CIPN and HRQOL in the first 300 patients enrolled in a larger (1,060 total) multicenter phase III trial randomized to one of four adjuvant regimens: (1) anthracycline-cyclophosphamide followed by paclitaxel (ACP), (2) AC followed by docetaxel (ACD), (3) paclitaxel alone (PTX), or (4) docetaxel alone (DTX). CIPN was assessed by the Patient Neurotoxicity Questionnaire (PNQ) and the National Cancer Institute Common Toxicity Criteria, and HRQOL by Functional Assessment of Cancer Therapy-General (FACT-G). CIPN and HRQOL scores were compared between ACP and ACD vs. PTX and DTX, and ACP and PTX vs. ACD and DTX. PNQ sensory scores were significantly higher in patients treated with taxane monotherapy compared to treatment with AC followed by taxane (P = .003). No significant differences in PNQ sensory scores were observed between the ACP and PTX vs. ACD and...Continue Reading

References

Apr 13, 1995·The New England Journal of Medicine·E K Rowinsky, R C Donehower
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F CellaJ Brannon
Jul 1, 1996·Annals of Internal Medicine·K ShanJ B Young
Sep 18, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T J PostmaN K Aaronson
Jul 25, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T J Postma, J J Heimans
Mar 2, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·H FumimotoS Kudoh
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E A CalhounD Cella
Jan 14, 2004·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shozo Ohsumi, Yoshihide Sunada
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric P WinerLarry Norton
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Erik K FrommeTomasz M Beer
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S E JonesP M Ravdin
Feb 14, 2006·Seminars in Oncology·Frederick H HausheerFrank Lieberman
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J Lee, Sandra M Swain
Apr 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Morten Aa PetersenMogens Groenvold
Oct 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vernon HarveySoeren Cold
Mar 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H Q HuangG Fleming
Nov 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff A SloanUNKNOWN National Cancer Institute
Mar 11, 2008·Critical Reviews in Oncology/hematology·Andreas A ArgyriouHaralabos P Kalofonos
Apr 19, 2008·The New England Journal of Medicine·Joseph A SparanoNancy E Davidson
Jun 24, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sherry WolfCharles Loprinzi
Dec 18, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Katsumasa KuroiFrederick H Hausheer
Mar 31, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kojiro ShimozumaFrederick H Hausheer

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Citations

Apr 4, 2013·JAMA : the Journal of the American Medical Association·Ellen M Lavoie SmithUNKNOWN Alliance for Clinical Trials in Oncology
May 10, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shozo Ohsumi, Kojiro Shimozuma
Jul 31, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Michael BaldwinDeanna L Kroetz
Jan 24, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Makoto NagashimaRyoji Katoh
May 14, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Eun Joo YangJae-Young Lim
May 3, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Floortje MolsLonneke van de Poll-Franse
Mar 5, 2014·CA: a Cancer Journal for Clinicians·Susanna B ParkMatthew C Kiernan
Jul 1, 2014·Journal of the Peripheral Nervous System : JPNS·Guido Cavaletti
Jan 31, 2013·Clinical Journal of Oncology Nursing·Ellen M Lavoie Smith
Aug 16, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·T ShiroiwaH Mukai
May 21, 2015·Revista da Escola de Enfermagem da U S P·Talita Cassanta CostaMarcia Maria Fontão Zago
Jul 14, 2016·F1000Research·James Addington, Miriam Freimer
Jan 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cindy TofthagenSusan McMillan
Feb 17, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Su Jeong SongJu-Yeun Lee
Apr 28, 2015·Toxics·Roser Velasco, Jordi Bruna
Mar 14, 2020·Breast Cancer Research and Treatment·Theodore S JennaroDaniel L Hertz
Oct 28, 2019·Journal of the Peripheral Nervous System : JPNS·Stefano TamburinAndreas A Argyriou
Oct 8, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ya-Jung WangLiang-Chih Liu
Apr 29, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel L HertzN Lynn Henry
Apr 28, 2021·Current Opinion in Supportive and Palliative Care·Rosario Privitera, Praveen Anand
Jun 17, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Tatsunori MurataHirohumi Mukai
Aug 15, 2021·Cancer Medicine·Mandana KamgarMichael S Simon
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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