PMID: 11899360Mar 20, 2002Paper

Taxanes and capecitabine in combination: rationale and clinical results

Clinical Breast Cancer
James F Maher, M A Villalona-Calero

Abstract

The clinical utility of capecitabine as a single agent in metastatic breast cancer has been demonstrated with significant responses seen in women already treated with anthracyclines and taxanes. A phase II study in older women with metastatic breast cancer demonstrated capecitabine to be an effective front-line therapeutic agent. Clinical trials of capecitabine in combination with the taxanes, paclitaxel and docetaxel, have been based on the observed upregulation of thymidine phosphorylase (TP) in preclinical studies. This taxane-mediated upregulation is synergistic, time dependent, and persists for up to 10 days. Studies of taxanes administered every 3 weeks with capecitabine have shown favorable antitumor responses and the combination of a taxane with capecitabine was favored over a taxane alone. The day-to-day administration of taxanes and capecitabine led to toxicity concerns, which have hindered their daily use. The administration of taxanes on a weekly schedule has demonstrated a more favorable toxicity profile (i.e., less myelosuppression), and initial studies in combination with capecitabine have demonstrated their utility in various solid tumors. Schedule optimization based on the upregulation of TP may result in a gre...Continue Reading

Citations

Nov 18, 2004·Cancer Science·Shin-ichi AkiyamaMisako Haraguchi
Aug 12, 2010·Cancer Chemotherapy and Pharmacology·Yen-Shen LuChiun-Sheng Huang
Feb 25, 2014·Cancer Chemotherapy and Pharmacology·Heloisa P SoaresCaio M Rocha-Lima
Sep 21, 2016·BMJ Open Gastroenterology·Alex Yuang-Chi ChangKhong Hee Lim
Jan 24, 2014·Japanese Journal of Clinical Oncology·Lei ChenHui Wang
Jan 28, 2014·Anti-cancer Drugs·E Gabriela Chiorean, Daniel D Von Hoff
Sep 15, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Florence AtrafiMartijn P Lolkema

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