Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Md Wasimul HaqueShakti P Pattanayak

Abstract

7,12-dimethylbenz(a)anthracene(DMBA), a PAH derivative initializes cascades of signaling events that alters a variety of enzymes responsible for lipid and glucose homeostasis resulting in enhanced availability and consumption of energy producing molecules for the development of carcinogenesis. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR) is a key enzyme regulating the pathway of synthesis of cholesterol whereas liver-X-receptor (LXR) regulates lipid, carbohydrate metabolism in various malignancies including mammary carcinogenesis (MC). In this study Taxifolin (TAX), a potential flavanoid has been subjected to evaluate its anti-cancer potential on (MC). We designed to screen the molecular docking analysis of TAX on LXRα, LXRβ, HMG-CoAR, mTOR and PTEN using MAESTRO tool comparing with their reference ligands. MC was developed by the administration of DMBA in the air pouch (under the mammary fat pad) of the female Sprague-Dawley rats (55 days old). After 90 days of cancer induction, the chemotherapeutic potential of TAX was evaluated by administering TAX at different doses (10, 20 and 40 mg/kg b.w./day). Then western blot and RT-qPCR analysis were performed for determination of the protein and mRNA expressions respec...Continue Reading

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Citations

Nov 15, 2018·International Journal of Molecular Sciences·Salvatore ChirumboloTaras Upyr
Aug 1, 2020·Cell Death & Disease·Kui ChenDong-Fu Feng
Feb 23, 2021·Journal of Molecular Modeling·Chuanjiong LinJinku Bao
Apr 20, 2021·Toxicological Research·Stephen SafeRupesh Shrestha
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis Gustavo Saboia PonteFernando Moreira Simabuco
Aug 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abhijit DasSouvik Roy

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