Mar 29, 2018

taxMaps: comprehensive and highly accurate taxonomic classification of short-read data in reasonable time

Genome Research
André CorveloMichael C Zody

Abstract

High-throughput sequencing is a revolutionary technology for the analysis of metagenomic samples. However, querying large volumes of reads against comprehensive DNA/RNA databases in a sensitive manner can be compute-intensive. Here, we present taxMaps, a highly efficient, sensitive, and fully scalable taxonomic classification tool. Using a combination of simulated and real metagenomics data sets, we demonstrate that taxMaps is more sensitive and more precise than widely used taxonomic classifiers and is capable of delivering classification accuracy comparable to that of BLASTN, but at up to three orders of magnitude less computational cost.

  • References24
  • Citations6

References

Mentioned in this Paper

Classification
DNA-like RNA
RNA Databases
Streams
Metagenomics
Computer Programs and Programming
Sequencing
High-Throughput Nucleotide Sequencing
Simulation
Clinical Classifications Software

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